Browsing by Author "Corbett, Chris"

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    A 3-year follow-up study after treatment with simeprevir in combination with pegylated interferon-α and ribavirin for chronic hepatitis C virus infection
    (2018-01-30) Zoulim, Fabien; Moreno, Christophe; Lee, Samuel S; Buggisch, Peter; Horban, Andrzej; Lawitz, Eric; Corbett, Chris; Lenz, Oliver; Fevery, Bart; Verbinnen, Thierry; Shukla, Umesh; Jessner, Wolfgang
    Abstract Background Simeprevir is approved with pegylated interferon and ribavirin (PR) for chronic hepatitis C virus (HCV) genotype (GT) 1 and GT4 infection in the USA and the European Union. Methods This 3-year follow-up study assessed the durability of sustained virologic response (SVR) (undetectable HCV RNA 12 or 24 weeks after treatment end), and evaluated the persistence of treatment-emergent NS3/4A protease inhibitor resistance in patients not achieving SVR following treatment with simeprevir plus PR in the parent study. The maintenance of SVR after the last post-therapy follow-up visit of the parent study (LPVPS) was assessed using HCV RNA measurements. The persistence of treatment-emergent NS3 amino acid substitutions in patients with no SVR at LPVPS was assessed using population sequencing. No study medications were administered. Results Overall, 249 patients were enrolled (200 with SVR at LPVPS; 49 with no SVR at LPVPS); 40 patients discontinued prematurely (18 with SVR; 22 with no SVR). All 200 enrolled patients who achieved SVR in the parent study maintained SVR until the last available visit in this study (median follow-up time: 35.8 months). The treatment-emergent NS3 amino acid substitutions detected at time of failure in the parent study in 43/49 enrolled patients were no longer detected in 37/43 (86.0%) at the end of this study (median follow-up time: 179.9 weeks [41.3 months]). Conclusion This 3-year follow-up study provides evidence for the long-term durability of SVR (100%) after successful treatment with simeprevir plus PR. Treatment-emergent NS3 amino acid substitutions became undetectable in the majority of patients. Trial registration NCT01349465; ClinicalTrials.gov .
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    FIG/PIC USER'S GUIDE
    (1981-12-01) Corbett, Chris; Witten, Ian H.
    Fig is a preprocessor to troff which allows figures consis ting of arbitrary graphics to be included within formatted text. Such graphics can come from a variety of sources, presented in the form of figures defined within the text, Unix plot files and raw raster files. Figures defined within the text are specified in the PIC language, and thus fig contains a PIC interpreter. The basic objects in PIC are boxes, lines, arrows, circles, arcs, and ellipses. These may be placed anywhere and labelled with arbitrary text. This report is a compendium of documents which give the information needed to get started with fig and PIC.
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    HOST-SATELLITE SOFTWARE TOOLS FOR MICROCOMPUTER SYSTEMS
    (1981-12-01) Corbett, Chris; Witten, Ian H.
    Microprocessor hardware and software is usually commissioned with the aid of a dedicated support tool, be it a `universal' or manufacturer-specific development system. This paper outlines a different support facility for microprocessors based on a general purpose host and a star network of microprocessor satellites. The host-satellite configuration is described, together with a suitable structure for the satellites. Two levels of host-satellite interaction are then discussed: one facilitates the software development cycle only, while the second adds extensive run-time support by allowing each satellite access to host file systems and other resources. Finally we describe the generation of software tools such as cross assemblers and cross compilers, using examples from an existing system with a PDP-11/Unix host.
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    ON THE INCLUSION AND PLACEMENT OF DOCUMENTATION GRAPHICS IN COMPUTER TYPESETTING
    (1981-09-01) Corbett, Chris; Witten, Ian
    Computer typesetting systems can produce high quality printed pages suitable for the production of books, journals, and newspapers in final form. Little effort to date has been applied to the problem of including and placing arbitrary graphic figures within processed text. In this paper we describe a system, constructed around existing typesetting software, which allows figure definition and placement. Key features of the system are a wide range of figure sources; figure preview facilities; figures-only output and compatibility with non-graphic printing devices, where figures are plotted separately; support of a figure language for in-line figure definition; and figure placement algorithms which are changeable at the user level.