Browsing by Author "Desch, Gertrud Wolfgang"

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    A novel three-filament model of force generation in eccentric contraction of skeletal muscles
    (PLOS One, 2015-01) Schappacher-Tilp, Gudrun; Leonard, Timothy R.; Desch, Gertrud Wolfgang; Herzog, Walter
    We propose and examine a three filament model of skeletal muscle force generation, thereby extending classical cross-bridge models by involving titin-actin interaction upon active force production. In regions with optimal actin-myosin overlap, the model does not alter energy and force predictions of cross-bridge models for isometric contractions. However, in contrast to cross-bridge models, the three filament model accurately predicts history-dependent force generation in half sarcomeres for eccentric and concentric contractions, and predicts the activation-dependent forces for stretches beyond actin-myosin filament overlap.