Browsing by Author "Dhaliwal, Raveena"

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    Magnetic Resonance Imaging of Demyelination and Remyelination in the Lysolecithin Model of Multiple Sclerosis
    (2017-02) Dhaliwal, Raveena; Dunn, Jeff F.; Yong, V. Wee; Pike, Bruce; Ousman, Shalina
    We require magnetic resonance imaging methods sensitive to remyelination for evaluation of remyelinating therapies for multiple sclerosis (MS). The goal of this thesis was to characterize the sensitivity of quantitative magnetization transfer (qMT) and diffusion tensor imaging (DTI) to myelin and axonal loss and remyelination in the lysolecithin model. This model is being used to develop remyelinating therapies for MS. We found that the qMT parameters of bound pool fraction (f), T1 and several DTI parameters were able to detect demyelination in the lysolecithin model. The qMT parameters did not change with remyelination but several DTI parameters did recover slightly. f had the strongest correlation to the histological measure of myelin and T1 had the strongest correlation to the histological measure of axon content. Overall, the findings from this thesis support the inclusion of DTI and qMT as an outcome measure in future studies of potential MS therapeutics in the lysolecithin model.