Browsing by Author "Faes, Camille"

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    Correction to: Effectiveness of an individualized home-based physical activity program in surgery-free non-endarterectomized asymptomatic stroke patients: a study protocol for the PACAPh interventional randomized trial
    (2022-03-22) Mura, Mathilde; Rivoire, Emeraude; Dehina-Khenniche, Leila; Weiss-Gayet, Michèle; Chazaud, Bénédicte; Faes, Camille; Connes, Philippe; Long, Anne; Rytz, Chantal L.; Mury, Pauline; Delrieu, Lidia; Gouraud, Etienne; Bordet, Marine; Della Schiava, Nellie; Lermusiaux, Patrick; Arsicot, Matthieu; Millon, Antoine; Pialoux, Vincent
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    Effectiveness of an individualized home-based physical activity program in surgery-free non-endarterectomized asymptomatic stroke patients: a study protocol for the PACAPh interventional randomized trial
    (2022-02-14) Mura, Mathilde; Rivoire, Emeraude; Dehina-Khenniche, Leila; Weiss-Gayet, Michèle; Chazaud, Bénédicte; Faes, Camille; Connes, Philippe; Long, Anne; Rytz, Chantal L.; Mury, Pauline; Delrieu, Lidia; Gouraud, Etienne; Bordet, Marine; Schiava, Nellie D.; Lermusiaux, Patrick; Arsicot, Matthieu; Millon, Antoine; Pialoux, Vincent
    Abstract Background Carotid atherosclerotic plaques remain silent until their rupture, which may lead to detrimental ischemic events such as strokes. This is due, in part, to intraplaque hemorrhages (IPH) and the resulting inflammatory processes, which may promote carotid plaque vulnerability. Currently, the benefits of carotid endarterectomy remain unclear for asymptomatic patients. Interestingly, the completion of physical activity (PA) may have beneficial effects; however, the paucity of current data warrants robust longitudinal interventions. We therefore aim to study the effects of a 6-month longitudinal personalized home-based PA program on IPH, biological, and inflammatory markers in asymptomatic stroke patients. Methods Eighty patients (≥ 18 years old) will be recruited for the Physical Activity and Carotid Atherosclerotic Plaque Hemorrhage (PACAPh) clinical trial from the Hospices Civils de Lyon. Patients will be eligible if they present with carotid stenosis ≥ 50% and are asymptomatic from any ischemic events for at least 6 months. Recruited patients will be randomized into either a PA or a control group, and assessed at baseline and after 6 months. At both time points, all patients will be assessed using magnetic resonance imaging to assess IPH, blood sampling to measure inflammatory markers and monocytic phenotyping, PA and sedentary behavior questionnaires, 6-min walking test, and maximal isometric quadricep contraction test. The randomized PA intervention will consist of reaching a daily walking step goal individually tailored to each patient. Steps will be collected using a wirelessly connected wristband. The number of steps completed by individuals in the PA group will be re-evaluated bimonthly to encourage walking habits. Discussion The PACAPh study is the first of its kind representing a feasible, easily accessible therapeutic strategy for asymptomatic stroke patients. We hypothesize that the personalized home-based PA program will reduce IPH and modulate inflammatory and biological parameters in patients presenting with carotid plaques. If the results of the PACAPh study prove to be beneficial on such health parameters, the implementation of such kind of intervention in the daily treatment of these patients would be an advantageous and cost-effective practice to adopt globally. Trial registration This study has been approved by the National Ethics Committee (IDRCB:2019-A01543-54/SI:19.06.21.40640). ClinicalTrials.gov NCT04053166
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    Role of Gender and Physical Activity Level on Cardiovascular Risk Factors and Biomarkers of Oxidative Stress in the Elderly
    (2020-06-19) Raberin, Antoine; Connes, Philippe; Barthélémy, Jean-Claude; Robert, Pia; Celle, Sébastien; Hupin, David; Faes, Camille; Rytz, Chantal; Roche, Frédéric; Pialoux, Vincent
    Background. Cardiovascular diseases remain as the leading cause of morbidity and mortality in industrialized countries. Ageing and gender strongly modulate the risk to develop cardiovascular diseases but very few studies have investigated the impact of gender on cardiovascular diseases in the elderly, which represents a growing population. The purpose of this study was to test the impact of gender and physical activity level on several biochemical and clinical markers of cardiovascular risk in elderly individuals. Methods. Elderly individuals (318 women ( years-old) and 227 men ( years-old)) were recruited. Physical activity was measured by a questionnaire. Metabolic syndrome was defined using the National Cholesterol Education Program Expert Panel’s definition. Polysomnography and digital tonometry were used to detect obstructive sleep apnea and assess vascular reactivity, respectively. Blood was sampled to measure several oxidative stress markers and adhesion molecules. Results. The frequency of cardiovascular diseases was significantly higher in men (16.4%) than in women (6.1%) (). Body mass index ( vs. ) and glycaemia ( vs. ) were lower, and High Density Lipoprotein (HDL) ( vs. ) was higher in women compared to men (). Oxidative stress was lower in women than in men (uric acid: vs. , advanced oxidation protein products: vs. , malondialdehyde: vs. ). Physical activity was not associated with lower cardiovascular risk factors in both genders. Multivariate analyses showed an independent effect of gender on acid uric (;), advanced oxidation protein products (;), and HDL concentration (;).Conclusion. These findings suggest that biochemical cardiovascular risk factors are lower in women than men which could explain the lower cardiovascular disease proportion observed in women in the elderly.