Browsing by Author "Frank, Cyril B."
Now showing 1 - 19 of 19
Results Per Page
Sort Options
Item Open Access A Biomechanical evaluation of orthotopic ligament transplantation in a rabbit model(1991) King, Graham J. W.; Frank, Cyril B.Item Open Access Analysis of patellofemoral joint vibration signals(1992) Ladly, Katherine Olivia; Frank, Cyril B.Item Open Access Biomechanical creep of rabbit medial collateral ligament autografts(1998) Boorman, Richard; Frank, Cyril B.Item Open Access Characterization of proteoglycan 4 and hyaluronan composition and function of ovine synovial fluid following knee surgery(2012) Barton, Kristen; Frank, Cyril B.; Schmidt, TanninItem Open Access Clonal analysis of synovial fluid-derived mesenchymal stems cells in a porcine model(2012) Kutcher, Josh; Frank, Cyril B.; Hart, David A.Mesenchymal stem cells (MSCs) were isolated from porcine synovial fluid (SF), and clonal populations derived through limiting dilution. Eighteen clones from three pigs (6 per pig) were then analyzed for their proliferative and differentiation characteristics. All 18 clones were able to undergo at least 25 population doublings, suggesting a high self-renewal capability. Their differentiation properties were assessed using histological stains and RT-PCR. Less than 50% of clones were capable of osteogenic differentiation, while greater than 75% were bipotent chondro-adipo progenitors; a phenotype never reported in other tissue types. In addition, all but one clone differentiated into chondrocytes, indicating an enhanced potential for cartilage regeneration. Despite using clonal populations, a great deal of variation was present between clones showing distinct differentiation potentials. The presented study suggests that clonal analysis is an effective method of identifying subpopulations in porcine SF, and that SF-derived MSCs may be an ideal tissue source for regenerating cartilage.Item Open Access In vitro characterization of fatigue damage in the medial collateral ligament of the knee(2007) Zec, Michelle; Shrive, Nigel G.; Frank, Cyril B.Item Open Access Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid(BioMed Central, 2012-07-23) Rattner, Jerome B.; Heard, Bryan J.; Martin, Liam; Frank, Cyril B.; Hart, David A.; Krawetz, RomanItem Open Access Optical communication between cells in chemically isolated systems(2003) Barnsdale, Christopher Alan; Frank, Cyril B.Item Open Access A pragmatic study exploring the prevention of delirium among hospitalized older hip fracture patients: Applying evidence to routine clinical practice using clinical decision support(BioMed Central, 2010-10-22) Holroyd-Leduc, Jayna M.; Abelseth, Greg A.; Khandwala, Farah; Silvius, James L.; Hogan, David B.; Schmaltz, Heidi N.; Frank, Cyril B.; Straus, Sharon EItem Open Access Quantification of early site specific changes in travecular bone morphology by microcomputed tomography (uct): a post-traumatic ovine osteoarthritis model(2007) Brown, Jevon James Yardley; Frank, Cyril B.; Hallgrimsson, BenediktItem Open Access Recovery of a growing ligament following immobilization in a rabbit model(1991) Weir, Trudy M. B.; Frank, Cyril B.Item Open Access Stress states in cartilage during joint loading and indentation(1996) Malmqvist, Lara Lisa; Frank, Cyril B.Item Open Access Surface interactions and cartilage damage in two ovine models of stifle injury(2012) Beveridge, Jillian Elizabeth; Frank, Cyril B.Anterior cruciate ligament and meniscus tears are injuries that are known risk factors for post-traumatic OA in humans, presumably because of residual abnormal knee mechanics. This work sought to determine whether abnormal motion of the tibiofemoral joint surfaces was related to early cartilage damage in two ovine joint injury models: combined anterior cruciate and medial collateral ligament transection (ACL/MCLx), and lateral meniscectomy (Mx). Five descriptions of in vivo tibiofemoral inter-surface motion (i.e., "surface interactions") were selected based on their speculated relationship to mechanical mechanisms known to damage cartilage in vitro. The hypotheses were: H1. increasingly abnormal surface interactions would correlate with cartilage damage, H2. the number of significant correlations would be greatest in ACL/MCLx sheep, and H3. locations of cartilage damage would qualitatively coincide with. that of altered surface interactions. 21 sheep were allocated to four groups: 6 ACL/MCLx, 5 Mx, 4 sham-operated, and 6 non-operated controls. Baseline in vivo kinematics were measured prior to injury, and serially up to 20 weeks postinjury, and expressed as the difference from Intact. Cartilage damage was quantified and mapped at sacrifice. Repeated measures ANOVAs and Pearson correlation coefficients were used to determine whether surface interactions were significantly different from Intact and correlated with cartilage damage. Results partially supported the hypotheses. ACL/MCLx surface interactions were significantly abnormal, and 3/5 interactions correlated with the magnitude of cartilage damage but not its distribution. The number of significant correlations was greatest in ACL/MCLx sheep and had a cumulative effect on cartilage damage that was individual- and surface-specific, suggesting that different surface interactions may be more damaging in different individuals. Lateral compartment joint space was significantly reduced following meniscectomy, but only correlated with cartilage damage at discrete gait points for two surface interactions 20 weeks post-Mx, suggesting that surface interactions presently quantified did not reflect the primary mechanism responsible for damage in this model, likely contact stress. The presence of significant correlations between multiple surface interactions and cartilage damage in both injury models add strong support to the paradigm that altered mechanics play a pivotal role in the aetiology of early cartilage damage following these joint injuries.Item Open Access The Cellular changes in medial collateral ligament autotransplantation(1990) Edwards, Pamela E.; Frank, Cyril B.Item Open Access The Effects of immobilization on the growth and maturation of the rabbit medial collateral ligament(1988) Walsh, Suzanne; Frank, Cyril B.Item Embargo The effects of transforming growth factor beta 1 on rabbit medial collateral ligament cells and medial collateral ligament scar cells in vitro(1994) Joshi, Rohit; Frank, Cyril B.Item Open Access The Structure and function of the insertions of the rabbit medial collateral ligament : an experim(1990) Matyas, John Robert; Frank, Cyril B.Item Open Access Item Open Access The structure-function relationship of the extracellular matrix in the rabbit medial collateral ligament(1998) Cunningham, Kim Diane; Frank, Cyril B.