Browsing by Author "Haddad, Elie"

Now showing 1 - 3 of 3
  • Thumbnail Image
    ItemOpen Access
    Growth and weight gain in children with juvenile idiopathic arthritis: results from the ReACCh-Out cohort
    (2017-08-22) Guzman, Jaime; Kerr, Tristan; Ward, Leanne M; Ma, Jinhui; Oen, Kiem; Rosenberg, Alan M; Feldman, Brian M; Boire, Gilles; Houghton, Kristin; Dancey, Paul; Scuccimarri, Rosie; Bruns, Alessandra; Huber, Adam M; Watanabe Duffy, Karen; Shiff, Natalie J; Berard, Roberta A; Levy, Deborah M; Stringer, Elizabeth; Morishita, Kimberly; Johnson, Nicole; Cabral, David A; Larché, Maggie; Petty, Ross E; Laxer, Ronald M; Silverman, Earl; Miettunen, Paivi; Chetaille, Anne-Laure; Haddad, Elie; Spiegel, Lynn; Turvey, Stuart E; Schmeling, Heinrike; Lang, Bianca; Ellsworth, Janet; Ramsey, Suzanne E; Roth, Johannes; Campillo, Sarah; Benseler, Susanne; Chédeville, Gaëlle; Schneider, Rayfel; Tse, Shirley M L; Bolaria, Roxana; Gross, Katherine; Feldman, Debbie; Cameron, Bonnie; Jurencak, Roman; Dorval, Jean; LeBlanc, Claire; St. Cyr, Claire; Gibbon, Michele; Yeung, Rae S M; Duffy, Ciarán M; Tucker, Lori B
    Abstract Background With modern treatments, the effect of juvenile idiopathic arthritis (JIA) on growth may be less than previously reported. Our objective was to describe height, weight and body mass index (BMI) development in a contemporary JIA inception cohort. Methods Canadian children newly-diagnosed with JIA 2005–2010 had weight and height measurements every 6 months for 2 years, then yearly up to 5 years. These measurements were used to calculate mean age- and sex-standardized Z-scores, and estimate prevalence and cumulative incidence of growth impairments, and the impact of disease activity and corticosteroids on growth. Results One thousand one hundred forty seven children were followed for median 35.5 months. Mean Z-scores, and the point prevalence of short stature (height < 2.5th percentile, 2.5% to 3.4%) and obesity (BMI > 95th percentile, 15.8% to 16.4%) remained unchanged in the whole cohort. Thirty-three children (2.9%) developed new-onset short stature, while 27 (2.4%) developed tall stature (>97.5th percentile). Children with systemic arthritis (n = 77) had an estimated 3-year cumulative incidence of 9.3% (95%CI: 4.3–19.7) for new-onset short stature and 34.4% (23–49.4) for obesity. Most children (81.7%) received no systemic corticosteroids, but 1 mg/Kg/day prednisone-equivalent maintained for 6 months corresponded to a drop of 0.64 height Z-scores (0.56–0.82) and an increase of 0.74 BMI Z-scores (0.56–0.92). An increase of 1 in the 10-cm physician global assessment of disease activity maintained for 6 months corresponded to a drop of 0.01 height Z-scores (0–0.02). Conclusions Most children in this modern JIA cohort grew and gained weight as children in the general population. About 1 in 10 children who had systemic arthritis, uncontrolled disease and/or prolonged corticosteroid use, had increased risk of growth impairment.
  • Thumbnail Image
    ItemOpen Access
    Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain
    (2017-10-16) Asahchop, Eugene L; Meziane, Oussama; Mamik, Manmeet K; Chan, Wing F; Branton, William G; Resch, Lothar; Gill, M. J; Haddad, Elie; Guimond, Jean V; Wainberg, Mark A; Baker, Glen B; Cohen, Eric A; Power, Christopher
    Abstract Background In patients with HIV/AIDS receiving antiretroviral therapy (ART), HIV-1 persistence in brain tissue is a vital and unanswered question. HIV-1 infects and replicates in resident microglia and trafficking macrophages within the brain although the impact of individual ART drugs on viral infection within these brain myeloid cells is unknown. Herein, the effects of contemporary ART drugs were investigated using in vitro and in vivo models of HIV-1 brain infection. Results The EC50 values for specific ART drugs in HIV-infected human microglia were significantly higher compared to bone marrow-derived macrophages and peripheral blood mononuclear cells. Intracellular ART drug concentrations in microglia were significantly lower than in human lymphocytes. In vivo brain concentrations of ART drugs in mice were 10 to 100-fold less in brain tissues compared with plasma and liver levels. In brain tissues from untreated HIV-infected BLT mice, HIV-encoded RNA, DNA and p24 were present in human leukocytes while ART eradicated viral RNA and DNA in both brain and plasma. Interruption of ART resulted in detectable viral RNA and DNA and increased human CD68 expression in brains of HIV-infected BLT mice. In aviremic HIV/AIDS patients receiving effective ART, brain tissues that were collected within hours of last ART dosing showed HIV-encoded RNA and DNA with associated neuroinflammatory responses. Conclusions ART drugs show variable concentrations and efficacies in brain myeloid cells and tissues in drug-specific manner. Despite low drug concentrations in brain, experimental ART suppressed HIV-1 infection in brain although HIV/AIDS patients receiving effective ART had detectable HIV-1 in brain. These findings suggest that viral suppression in brain is feasible but new approaches to enhancing ART efficacy and concentrations in brain are required for sustained HIV-1 eradication from brain.
  • Thumbnail Image
    ItemOpen Access
    WAO International Scientific Conference (WISC 2016) Abstracts
    (2017-06-20) Bao, Jun; Wang, Yi-Hui; Liu, Quan-Hua; Bao, Yi-Xiao; Azouz, Nurit; Caldwell, Julie; Ray, Leanne; Rochman, Mark; Mingler, Melissa; Eilerman, Matthew; Wen, Ting; Myers, Jocelyn B; Hershey, Gurjit K; Kottyan, Leah; Martin, Lisa; Marc, Rothenberg; Gonzalez-Uribe, Victor; Del Rio-Chivardi, Jaime; Del Rio-Navarro, Blanca; Lou, Hongfei; Ma, Siyuan; Zhao, Yan; Cao, Feifei; He, Fei; Liu, Zhongyan; Wang, Chengshuo; Bachert, Claus; Zhang, Luo; Abrams, Elissa; Becker, Allan; Kandhare, Amit; Bodhankar, Subhash; Grossman, Nicole; Doros, Gheorghe; Laden, Francine; Fuhlbrigge, Anne; Wechsler, Michael; Pace, Wilson; Yawn, Barbara; Israel, Elliot; Lee, Junehyuk; Adler, Frederick; Kim, Peter; Huang, Yung F; Chen, Ying Y; Pan, Chiun Y; Lee, Herng S; Khalemsky, Michael; Schwartz, David G; Kolkhir, Pavel; Pogorelov, Dmitry; Kochergin, Nikolay; Komarow, Hirsh; Young, Michael; Eisch, Robin; Scott, Linda; Metcalfe, Dean; Singer, Alexander; Wakeman, Andrew; Gerstner, Thomas; Abrams, Elissa; Song, Woo-Jung; Shim, Ji-Su; Won, Ha-Kyeong; Kang, Sung-Yoon; Sohn, Kyoung-Hee; Kim, Byung-Keun; Jo, Eun-Jung; Kim, Min-Hye; Kim, Sang-Heon; Park, Heung-Woo; Kim, Sun-Sin; Chang, Yoon-Seok; Morice, Alyn H; Lee, Byung-Jae; Cho, Sang-Heon; Min, Kyung-Up; Boscolo, Maria A; Brivio, Giulio; Bosisio, Sergio; Manzocchi, Nicoletta; Pulixi, Edoardo; Grignani, Giulia; D’Andrea, Eloisia; Ricci, Massimo; Passini, Elena; Italia, Maurizio; Urrutia-Pereira, Marilyn; Fagundes, Stefani; Oliano, Vinicius J; Solé, Dirceu; Benzaquen, Sadia; Aragaki, Alejandro; Balestra, Ricardo; Harden, Dawn; Caudell-Stamper, Danielle; Glady, Gilbert; Holbreich, Mark; Lyakhovska, Nataliya; Kaidashev, Igor; Bystron, Jaromir; Hutyrova, Beata; Balakirski, Galina; Vanstreels, Luk; Wurpts, Gerda; Merk, Hans F; Baron, Jens M; Plange, Johanna; Rihs, Hans-Peter; Raulf, Monika; Roeseler, Stefani; Tolcachier, Alberto; Chamorro, Armando; Otero, Ruth; Brooks, Joel; Hess, Michael; Benz, Jared; MacDonald, Joseph; Brooks, Joel; Benz, Jared; Chatha, Usma; Lent, Dale; Köse, Şükran; Tatar, Bengü G; Akkoçlu, Gülgün; Çukurova, İbrahim; Ödemiş, İlker; Toker, Ayşin K; Hasssan, Abdullahi; Gobir, Abdulrazaq A; Kim, Cheol-Woo; Choi, Young H; Lee, Jeong H; Cho, Rae J; Nam, Yu R; Nam, Joo H; Kim, Woo K; Filipovic, Ivana; Zivkovic, Zorica; Filipovic, Djordje; Shik, Dana; Smith, Andrew; Hsi, Wang Y; Friedman, Stuart; Gizaw, Yonatan; Bakhda, Rima; Mohammed, Kumail; Wasserman, Richard; Hague, Angela; Pence, Deanna; Rolen, Joanna; Sugerman, Robert; Silvers, Stacy; Kamili, Qurat; Knauer, Nadezhda; Zazernyi, Alexandr; Blinova, Elena; Demina, Daria; Kozlov, Vladimir; Agrawal, Komal; Kale, Sagar; Arora, Naveen; Vasilkova, Volha; Mokhort, Tatiana; Silvers, William; Eisenberg, Rachel; Mehta, Rushita; Rubinstein, Arye; Aston, Antony; Turner, Paul; Ruiz-Garcia, Monica; Boyle, Robert; Brown, Simon; Schejter, Yael D; Ovadia, Adi; Kim, Vy; Reid, Brenda; Roifman, Chaim; Rosenfield, Lana; Avilla, Ernie; Harada, Laurie; Allen, Marilyn; Waserman, Susan; Yoon, Ho J; Koo, Gun W; Chang, Suk-Il; Yoon, Hye-Ran; Park, Dong W; Park, Tai S; Moon, Ji-Yong; Kim, Sang-Heon; Kim, Tae H; Sohn, Jang W; Shin, Dong H; Jorjoliani, Tsici; Jorjoliani, Lia; Adamia, Nino; katamadze, Nona; Ramachandra, Deepika; Jorjoliani, Liana; Karseladze, Rusudan; Saginadze, Lali; Adamia, Nino; Chkuaseli, Natalia; Dolgova, Anna; Stukolova, Olga; Sudina, Anna; Cherkashina, Anna; Shipulin, German; Brivio, Giulio; Boscolo, Maria A; Rosenthal, Richard; Howe, Harvey; Knause, Paul; Greemberg, Rony; De Bruycker, Jean J; Fernandez, Isabel; Le Deist, Françoise; Haddad, Elie; Rha, Yeong H; Lee, Kyung S; Choi, Sun H; Tam, Herman; Simons, Estelle; Simons, Elinor; Golebiowska-Wawrzyniak, Maria; Markiewicz, Katarzyna; Faitelson, Yoram; Stein, Miguel; Mandelberg, Avigdor; Dalal, Ilan; Levin, Michael; Hobane, Lelani; Basera, Wisdom; Botha, Maresa; Gray, Claudia; Zar, Heather; Kjaeva, Biserka J; Arsovski, Zoran; Grivcheva-Panovska, Vesna; Odebode, Adeyinka; Adekunle, Adedotun; Adeonipekun, Peter; Farombi, Ebenezer; Camacho-Ordoñez, Nadezhda; Martinez-Vázquez, Alejandrina J; García-Cruz, María d l L H; Tan, Qi; Min, Rui; Dai, Guan-qun; Xie, Wei-Ping; Mao, Huang; Wang, Hong; Yadav, Rakesh; Singh, Sneha; Yadav, Divya; Khaleva, Ekaterina; Bahnson, Henry T; Franz, Amber; Garvey, Lene H; Jay, Nicola; Haque, Rubaiyat; Fox, Adam; Lack, Gideon; du Toit, George; Radic, Snezana; Milenkovic, Branislava; Neskovic, Ana; Danojevic, Ljiljana; Nachshon, Liat; Goldberg, Michael; Levy, Michael; Katz, Yitzhak; Elizur, Arnon; Rosario, Cristine; Kasper, Juliana; Chong-Neto, Herbeto; Riedi, Carlos; Rosario, Nelson; Elizur, Arnon; Levy, Michael B; Har-Even, Ronly; Nachshon, Liat; Carmel, Mor; Goldberg, Michael R; Kherkheulidze, Maia; Kavlashvili, Nani; Kandelaki, Eka; Adamai, Nino; Kherkheulidze, Maia; Jorjoliani, Lia; Ubiria, Irma; Burke, Andrea; Avilla, Ernie; Kastner, Monika; Waserman, Susan; Zheleva, Denica; Darlenski, Razvigor; Bozinakis, Konstantinos; Kriebardis, Anastasios; Styliara, Sofia; Karastathi, Aikaterini; Farmakas, Nikolaos; Ribeiro, Maria L K K; Barcellos, Ana C; Silva, Hannah G F; Carletto, Luís H M; Bet, Marcela C; Rossetto, Nathalia Z; Rosario, Nelson A; Chong-Neto, Herberto J; Valença, Fernanda; Novaes, Marina; Gomes, Mariana; Seifert, Carla; Neto, Alfredo; Loyola, Flavia; Rios, José; Silva, Tatiana; Neves, Aline; Novaes, Marina; Valença, Fernanda; Gomes, Mariana; Neto, Alfredo; Loyola, Flavia; Rios, José; Abadoglu, Oznur; Gemicioglu, Bilun; Bayram, Hasan; Cimrin, Arif; Akyildiz, Levent; Cilli, Aykut; Gunen, Hakan; Ozlu, Tevfik; Suerdem, Mecit; Uzaslan, Esra; Misirligil, Zeynep; Milenkovic, Branislava; Radic, Snezana; Ristic-Stojanovic, Snezana; Milicevic, A.; Milenkovic, A.; Cvejic, Jelena; Jankovic, Jelena; Dimic-Janjic, Sanja; Djurdjevic, Natasa; Barzylovych, Vladyslava; Umanets, Tetiana; Barzylovych, Anastasia; Winkler, Karyn; Margarinos, Jessica; Martin, Dylan; Nowakowski, Maja; Joks, Rauno; Stein, Miguel; Zangen, Tsili; Bernadsky, Olga; Boaz, Mona; Hermann, Gratiana; Faitelson, Yoram; Dalal, Ilan; Aviv, Rachel; Kuperboim, Olga; Ramichanov, Larisa; Broide, Efrat; Shamir, Raanan; Zevit, Noam; Shaoul, Ron; Fich, Alex; Levine, Arie; Ovadia, Adi; Schejter, Yael D; Roifman, Chaim; Melamed, Isaac; Gangwar, Roopesh S; Minai-Fleminger, Yael; Seaf, Mansour; Gutgold, Amichai; Shikotra, Aarti; Chauhan, Anoop; Holgate, Stephen; Bradding, Peter; Howarth, Peter; Eliashar, Ron; Berkman, Neville; Levi-Schaffer, Francesca; Woo, Sung-il; Celik, Betul; Bulut, Tangul; Yalcin, Arzu D; Celik, Betul; Yalcin, Arzu D; Bulut, Tangul; Caldas, Luiz Q; Confino-Cohen, Ronit; Rosman, Yossi; Goldberg, Arnon; Breuer, Oded; Singh, Roopesh; Seaf, Mansour; Barhoum, Ahlam; Kerem, Eitan; Levi-Schaffer, Francesca; Slavyanskaya, Tatiana; Sepiashvili, Revaz; Blinova, Elena A; Pashkina, Ekaterina A; Leonova, Marina I; Nepomnyaschikh, Vera M; Demina, Darya V; Kozlov, Vladimir A; Shamri, Revital; Young, Kristen M; Weller, Peter F; de Paula Vieira, Rodolfo; Oliveira-Junior, Manoel C; Damasceno-Rodrigues, Nilsa R; Arantes-Costa, Fernanda M; Martins, Milton A; Oliveira, Ana P L; Bernard, Alfred; Sardella, Antonia; Voisin, Catherine; Royce, Simon; Philpott, Hamish; Nandurkar, Sanjay; Thien, Francis; Gibson, Peter; Bianchini, Rodolfo; Roth-Walter, Franziska; Ohradanova-Repic, Anna; Hofstetter, Gerlinde; Herrmann, Ina; Carvalho, Maria I; Hufnagl, Karin; Bajna, Erika; Roth, Georg; Stockinger, Hannes; Jensen-Jarolim, Erika; Almog, Meital; Kessel, Aharon; Apov, Larisa; Salguero, Carlos S; Chacon, Alvaro S; Nazarov, Abbos; Ergashev, Shaxbos; Nesterova, Irina; Kovaleva, Svetlana; Chudilova, Galina; Lomtatidze, Ludmila; De Schryver, Sarah; Dery, Alizee; Clarke, Ann; Nadeau, Kari; Harada, Laurie; Weatherall, Kimberly; Greenwood, Celia; Daley, Denise; Asai, Yuka; Ben-Shoshan, Moshe; Balmasova, Irina; Malova, Elena; Hufnagl, Karin; Wagner, Stefanie; Pacios, Luis F; Wallner, Michael; Wiederstein, Markus; Hofstetter, Gerlinde; Roth-Walter, Franziska; Jensen-Jarolim, Erika; Tevs, Anna E; Pashkina, Ekaterina A; Leonova, Marina I; Nepomnyaschikh, Vera M; Demina, Darya V; Kozlov, Vladimir A; Blinova, Elena A; Tataurshchikova, Nataly; Sangidorj, Baigalmaa; Ronzhina, Anna; Sepiashvili, Revaz; Slavyanskaya, Tatiana; Chikhladze, Manana; Wirz, Oliver F; van de Veen, Willem; Mirer, David; Morita, Hideaki; Altunbulakli, Can; Johnston, Sebastian L; Glanville, Nicholas; Papadopoulos, Nikolaos G; Akdis, Cezmi A; Akdis, Mübeccel; Reshef, Avner; Riedl, Marc; Panovska, Vesna G; Moldovan, Dumitru; Baker, James; Yang, William H; Andrejevic, Sladjana; Lockey, Richard F; Hakl, Roman; Kivity, Shmuel; Bellizzi, Luca; Harper, Joseph R; Relan, Anurag; Cicardi, Marco