Browsing by Author "Handkamer, Kristen Claire"

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    Application of the reservoir-wave approach to the renal circulation
    (2012) Handkamer, Kristen Claire; Tyberg, John V.
    The reservoir-wave approach provided the idea that systemic vascular resistance could be modeled as several component resistors arranged in series. The purpose of this investigation was to apply the reservoir-wave approach to the renal circulation and examine how a renal venous constriction (RVC) or a renal arterial infusion of vasoactive agents into one kidney altered conductance, P oo, and series resistances. Endothelin-1 and Angiotensin 11 reduced conductance to 39.6 ± 5.1 and 64.4 ± 4.3%; total renal resistance increased but arterial reservoir resistance decreased to 64.8 ± 6.3 and 80.0 ± 6.1 % of the control respectively. Endothelin-1 and Angiotensin II also increased Poo by 14.5 ± 2.7 and l 0.2 ± 3.6 mmHg, and the microcirculatory plus venous resistance to 187.2 ± 21.0 and 180.0 ± 35.8% ofthe control respectively. RVC increased conductance to I 12.3 ± 4.4% of the control, in apparent compensation. The reservoir-wave approach is applicable to the renal circulation and its use in subsequent investigations is warranted.