Browsing by Author "Johns, Daniel G"

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    Seroprevalence of Cytomegalovirus, Toxoplasma gondii, Syphilis, and Hepatitis B and C Virus Infections in a Regional Population Seropositive for HIV Infection
    (1998-01-01) Johns, Daniel G; Gill, M John
    OBJECTIVE: To determine the prevalence of exposure to cytomegalovirus (CMV), Toxoplasma gondii, syphilis, hepatitis B virus (HBV) and hepatitis C virus (HCV) in a large, well characterized, regional population presenting for human immunodeficency virus (HIV) care.DESIGN: Demographic and serological data compiled prospectively in a relational database used for routine patient care. Results were analyzed for statistically significant trends within demographic subpopulations known to be at risk of such infections.PATIENTS AND SETTING: A total of 1274 persons with documented HIV infection in southern Alberta have sought medical care since 1985. Serological status to CMV, T gondii, syphilis, HBV and HCV infections were routinely requested as part of the initial assessment. All patients with serological results available were included in the analysis.RESULTS: CMV infection was found in 84.1% of patients. A lower prevalence of CMV infection in those under 30 yeasr old (Pud_less_than0.001), intravenous drug users (IVDUs) (P=0.001) and in patients with transfusion-acquired HIV (Pud_less_than0.001) was seen. T gondii seropositivity was found in 10.6% of patients, with an increased risk of seropositivity in those born outside of Canada (Pud_less_than0.001). Syphilis seropositivity was present in 5.1% of patients, with a higher prevalence in gay males (P=0.1). HBV carrier status was noted in 8.0% of patients, with males having an increased risk (P=0.025). Since 1990, there has been a 17.6% prevalence of HCV, predominantly in IVDUs (Pud_less_than0.001).CONCLUSION: Seroprevalence to common pathogens in HIV disease varies significantly among subpopulations, necessitating individual testing.