Browsing by Author "Lee, Laurie"

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    Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016
    (2017-04-07) Alsayegh, Mohammad A; Alshamali, Hanan; Khadada, Mousa; Ciccolini, Amanda; Ellis, Anne K; Quint, Diana; Powley, William; Lee, Laurie; Fiteih, Yahya; Baksh, Shairaz; Vliagoftis, Harissios; Gerega, Sebastien K; Millson, Brad; Charland, Katia; Barakat, Stephane; Sun, Xichun; Jimenez, Ricardo; Waserman, Susan; FitzGerald, Mark J; Hébert, Jacques; Cognet-Sicé, Josiane; Renahan, Kevin E; Huq, Saiful; Chooniedass, Rishma; Sawyer, Scott; Pasterkamp, Hans; Becker, Allan; Smith, Steven G; Zhang, Shiyuan; Jayasundara, Kavisha; Tacon, Claire; Simidchiev, Alex; Nadeau, Gilbert; Gunsoy, Necdet; Mullerova, Hana; Albers, Frank; Kim, Young W; Shannon, Casey P; Singh, Amrit; Neighbour, Helen; Larché, Mark; Tebbutt, Scott J; Klopp, Annika; Vehling, Lorena; Becker, Allan B; Subbarao, Padmaja; Mandhane, Piushkumar J; Turvey, Stuart E; Sears, Malcolm R; Azad, Meghan B; Loewen, Keely; Monchka, Barret; Mahmud, Salaheddin M; Jong, Geert ‘; Longo, Cristina; Bartlett, Gillian; Ducharme, Francine M; Schuster, Tibor; MacGibbon, Brenda; Barnett, Tracie; North, Michelle L; Brook, Jeff; Lee, Elizabeth; Omana, Vanessa; Thiele, Jenny; Steacy, Lisa M; Evans, Greg; Diamond, Miriam; Sussman, Gordon L; Amistani, Yann; Abiteboul, Kathy; Tenn, Mark W; Yang, ChenXi; Carlsten, Christopher; Conway, Edward M; Mack, Douglas; Othman, Yasmin; Barber, Colin M; Kalicinsky, Chrystyna; Burke, Andrea E; Messieh, Mary; Nair, Parameswaran; Che, Chun T; Douglas, Lindsay; Liem, Joel; Duan, Lucy; Miller, Charlotte; Dupuis, Pascale; Connors, Lori A; Fein, Michael N; Shuster, Joseph; Hadi, Hani; Polk, Brooke; Raje, Nikita; Labrosse, Roxane; Bégin, Philippe; Paradis, Louis; Roches, Anne D; Lacombe-Barrios, Jonathan; Mishra, Sanju; Lacuesta, Gina; Chiasson, Meredith; Haroon, Babar; Robertson, Kara; Issekutz, Thomas; Leddin, Desmond; Couban, Stephen; Connors, Lori; Roos, Adrienne; Kanani, Amin; Chan, Edmond S; Schellenberg, Robert; Rosenfield, Lana; Cvetkovic, Anna; Woodward, Kevin; Quirt, Jaclyn; Watson, Wade T A; Castilho, Edson; Sullivan, Jennifer A; Temple, Beverley; Martin, Donna; Cook, Victoria E; Mills, Christopher; Portales-Casamar, Elodie; Fu, Lisa W; Ho, Alexander; Zaltzman, Jeffrey; Chen, Lucy; Vadas, Peter; Gabrielli, Sofianne; Clarke, Ann; Eisman, Harley; Morris, Judy; Joseph, Lawrence; LaVieille, Sebastien; Ben-Shoshan, Moshe; Graham, François; Barnes, Charles; Portnoy, Jay; Stagg, Vincent; Simons, Elinor; Lefebvre, Diana; Dai, David; Mandhane, Piushkumar; Sears, Malcolm; Tam, Herman; Simons, F. E R; Alotaibi, Dhaifallah; Dawod, Bassel; Tunis, Matthew C; Marshall, Jean; Desjardins, Marylin; Béland, Marianne; Lejtenyi, Duncan; Drolet, Jean-Phillipe; Lemire, Martine; Tsoukas, Christos; Noya, Francisco J; Alizadehfar, Reza; McCusker, Christine T; Mazer, Bruce D; Maestre-Batlle, Danay; Gunawan, Evelyn; Rider, Christopher F; Bølling, Anette K; Pena, Olga M; Suez, Daniel; Melamed, Isaac; Hussain, Iftikhar; Stein, Mark; Gupta, Sudhir; Paris, Kenneth; Fritsch, Sandor; Bourgeois, Christelle; Leibl, Heinz; McCoy, Barbara; Noel, Martin; Yel, Leman; Scott, Ori; Reid, Brenda; Atkinson, Adelle; Kim, Vy H; Roifman, Chaim M; Grunebaum, Eyal; AlSelahi, Eiman; Aleman, Fernando; Oberle, Amber; Trus, Mike; Sussman, Gordon; Kanani, Amin S; Chambenoi, Olivier; Chiva-Razavi, Sima; Grodecki, Savannah; Joshi, Nikhil; Menikefs, Peter; Holt, David; Pun, Teresa; Tworek, Damian; Hanna, Raphael; Heroux, Delia; Rosenberg, Elli; Stiemsma, Leah; Turvey, Stuart; Denburg, Judah; Mill, Christopher; Teoh, Timothy; Zimmer, Preeti; Avinashi, Vishal; Paina, Mihaela; Darwish Hassan, Ahmed A; Oliveria, John P; Olesovsky, Chris; Gauvreau, Gail; Pedder, Linda; Keith, Paul K; Plunkett, Greg; Bolner, Michelle; Pourshahnazari, Persia; Stark, Donald; Vostretsova, Kateryna; Moses, Andrew; Wakeman, Andrew; Singer, Alexander; Gerstner, Thomas; Abrams, Elissa; Johnson, Sara F; Woodgate, Roberta L
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    Impact of restricted family presence during the COVID-19 pandemic on critically ill patients, families, and critical care clinicians: a qualitative systematic review
    (2024-08-15) Krewulak, Karla D.; Jaworska, Natalia; Lee, Laurie; Louis, Julia S.; Dmitrieva, Olesya; Leia, Madison P.; Doig, Christopher; Niven, Daniel J.; Parhar, Ken K. S.; Rochwerg, Bram; West, Andrew; Stelfox, Henry T.; Leigh, Jeanna P.; Fiest, Kirsten M.
    Abstract Background We aimed to synthesize the qualitative evidence on the impacts of COVID-19-related restricted family presence policies from the perspective of patients, families, and healthcare professionals from neonatal (NICU), pediatric (PICU), or adult ICUs. Methods We searched MEDLINE, EMBASE, Cochrane Databases of Reviews and Clinical Trials, CINAHL, Scopus, PsycINFO, and Web of Science. Two researchers independently reviewed titles/abstracts and full-text articles for inclusion. Thematic analysis was completed following appraising article quality and assessing confidence in the individual review findings using standardized tools. Results We synthesized 54 findings from 184 studies, revealing the impacts of these policies in children and adults on: (1) Family integrated care and patient and family-centered care (e.g., disruption to breastfeeding/kangaroo care, dehumanizing of patients); (2) Patients, families, and healthcare professionals (e.g., negative mental health consequences, moral distress); (3) Support systems (e.g., loss of support from friends/families); and (4) Relationships (e.g., loss of essential bonding with infant, struggle to develop trust). Strategies to mitigate these impacts are reported. Conclusion This review highlights the multifaceted impacts of restricted visitation policies across distinct care settings and strategies to mitigate the harmful effects of these policies and guide the creation of compassionate family presence policies in future health crises. Registration https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=290263 .
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    Rapid normalization of vitamin D deficiency in PICU (VITdALIZE-KIDS): study protocol for a phase III, multicenter randomized controlled trial
    (2024-09-19) O’Hearn, Katie; Menon, Kusum; Albrecht, Lisa; Amrein, Karin; Britz-McKibbin, Philip; Cayouette, Florence; Choong, Karen; Foster, Jennifer R.; Fergusson, Dean A.; Floh, Alejandro; Fontela, Patricia; Geier, Pavel; Gilfoyle, Elaine; Guerra, Gonzalo G.; Gunz, Anna; Helmeczi, Erick; Khamessan, Ali; Joffe, Ari R.; Lee, Laurie; McIntyre, Lauralyn; Murthy, Srinivas; Parsons, Simon J.; Ramsay, Tim; Ryerson, Lindsay; Tucci, Marisa; McNally, Dayre
    Abstract Background The rate of vitamin D deficiency (VDD) in critically ill children worldwide has been estimated at 50%. These children are at risk of multiple organ dysfunction, chronic morbidity, and decreased health related quality of life (HRQL). Pediatric and adult ICU clinical trials suggest that VDD is associated with worse clinical outcomes, although data from supplementation trials are limited and inconclusive. Our group’s phase II multicenter dose evaluation pilot study established the efficacy and safety of an enteral weight-based cholecalciferol loading dose to rapidly restore vitamin D levels in critically ill children. Methods Our aim is to evaluate the impact of this dosing regimen on clinical outcomes. VITdALIZE-KIDS is a pragmatic, phase III, multicenter, double-blind RCT aiming to randomize 766 critically ill children from Canadian PICUs. Participants are randomized using a 1:1 scheme to receive a single dose at enrollment of enteral cholecalciferol (10,000 IU/kg, max 400,000 IU) or placebo. Eligibility criteria include critically ill children aged newborn (> 37 weeks corrected gestational age) to < 18 years who have blood total 25-hydroxyvitamin D < 50 nmol/L. The primary objective is to determine if rapid normalization of vitamin D status improves HRQL at 28 days following enrollment. The secondary objective is to evaluate the impact of rapid normalization of vitamin D status on multiple organ dysfunction. The study includes additional tertiary outcomes including functional status, HRQL and mortality at hospital discharge and 90 days, PICU and hospital length of stay, and adverse events related to vitamin D toxicity. Additionally, we are performing comprehensive vitamin D speciation and non-targeted metabolite profiling as part of a sub-study for the first 100 participants from whom an enrollment and at least one post-intervention blood and urine sample were obtained. Discussion The VITdALIZE-KIDS trial is the first phase III, multicenter trial to evaluate whether rapid normalization of vitamin D status could represent a simple, inexpensive, and safe means of improving outcomes following pediatric critical illness. Recruitment was initiated in June 2019 and is expected to continue to March 2026. Trial registration Clinicaltrials.gov, NCT03742505. Study first submitted on November 12, 2018 https://clinicaltrials.gov/study/NCT03742505