Browsing by Author "Liu, Lei"

Now showing 1 - 2 of 2
  • Thumbnail Image
    ItemOpen Access
    Association between Cardiac Autonomic Neuropathy and Coronary Artery Lesions in Patients with Type 2 Diabetes
    (2020-12-30) Liu, Lei; Wu, Qiansheng; Yan, Hong; Chen, Baoxian; Zheng, Xilong; Zhou, Qiang
    Objective. Cardiac autonomic neuropathy (CAN) is a common and serious complication of diabetes mellitus with various systemic involvements, such as atherosclerotic cardiovascular disease. We aimed to evaluate the association between CAN and coronary artery lesions in patients with type 2 diabetes. Research Design and Methods. We retrospectively reviewed the medical records of 104 patients with type 2 diabetes and coronary artery disease (CAD). We evaluated heart rate variability (HRV) parameters (SDANN, SDNN, and pNN50) to assess cardiac autonomic function. The severity of coronary lesions was assessed by the Gensini scores and the number of affected vessels. Correlation analyses between HRV parameters and the severity of coronary lesions and clinical parameters were performed. Results. Spearman’s correlation analysis showed a significant negative correlation between SDANN and Gensini scores (,). Interestingly, this finding remained significant after adjusting for clinical covariates (,). However, there was no association between HRV parameters and the severity of coronary lesions as assessed by the number of affected vessels. Clinical parameters were not significantly correlated with HRV parameters (all ).Conclusions. Cardiac autonomic neuropathy might be related to the degree of coronary atheromatous burden in patients with type 2 diabetes. Screening for cardiac autonomic neuropathy might potentially be beneficial in the risk stratification of patients with type 2 diabetes.
  • Thumbnail Image
    ItemOpen Access
    Plasma Homocysteine and Autonomic Nervous Dysfunction: Association and Clinical Relevance in OSAS
    (2020-07-09) Liu, Lei; Wu, Qiansheng; Yan, Hong; Zheng, Xilong; Zhou, Qiang
    Objective. Elevated plasma homocysteine (Hcy) is an independent risk factor for cardiovascular diseases, but the precise mechanism of Hcy in cardiovascular disease remains elusive. This study is aimed at evaluating the association between Hcy levels and autonomic nervous system and at investigating their clinical relevance in obstructive sleep apnea syndrome (OSAS). Methods. A total of 191 subjects with OSAS were enrolled for this cross-sectional study. Heart rate variability (HRV) represents the status of the autonomic nervous system and is a well-known index that allows studying the autonomic modulation. HRV and polysomnography parameters were collected based on Holter monitors and polysomnography system. The software computed all the basic HRV parameters including SDANN, SDNN and pNN50. Correlation analyses between Hcy and HRV parameters and echocardiographic parameters were performed. Results. Compared with the mild-moderate OSAS group, the prevalence of male and smoking and Hcy levels were considerably higher in the severe OSAS group (,, and , respectively). Also, there were significant linear relationships between Hcy quartiles with the proportion of severe OSAS ( for the trend). Interesting, there is a negative linear correlation between SDANN and Hcy quartiles ( for the trend). Spearman’s correlation analysis showed a significant negative correlation between SDANN and Hcy levels (,). Interestingly, the relationship of it remains significant after adjustment for clinical covariates (,). However, echocardiographic parameters were not significantly correlated with Hcy or HRV parameters (all ).Conclusions. Elevated plasma Hcy level is linearly correlated with cardiac autonomic nervous function disorders in patients with OSAS.