Browsing by Author "Nair, Parameswaran"

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    ItemOpen Access
    Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016
    (2017-04-07) Alsayegh, Mohammad A; Alshamali, Hanan; Khadada, Mousa; Ciccolini, Amanda; Ellis, Anne K; Quint, Diana; Powley, William; Lee, Laurie; Fiteih, Yahya; Baksh, Shairaz; Vliagoftis, Harissios; Gerega, Sebastien K; Millson, Brad; Charland, Katia; Barakat, Stephane; Sun, Xichun; Jimenez, Ricardo; Waserman, Susan; FitzGerald, Mark J; Hébert, Jacques; Cognet-Sicé, Josiane; Renahan, Kevin E; Huq, Saiful; Chooniedass, Rishma; Sawyer, Scott; Pasterkamp, Hans; Becker, Allan; Smith, Steven G; Zhang, Shiyuan; Jayasundara, Kavisha; Tacon, Claire; Simidchiev, Alex; Nadeau, Gilbert; Gunsoy, Necdet; Mullerova, Hana; Albers, Frank; Kim, Young W; Shannon, Casey P; Singh, Amrit; Neighbour, Helen; Larché, Mark; Tebbutt, Scott J; Klopp, Annika; Vehling, Lorena; Becker, Allan B; Subbarao, Padmaja; Mandhane, Piushkumar J; Turvey, Stuart E; Sears, Malcolm R; Azad, Meghan B; Loewen, Keely; Monchka, Barret; Mahmud, Salaheddin M; Jong, Geert ‘; Longo, Cristina; Bartlett, Gillian; Ducharme, Francine M; Schuster, Tibor; MacGibbon, Brenda; Barnett, Tracie; North, Michelle L; Brook, Jeff; Lee, Elizabeth; Omana, Vanessa; Thiele, Jenny; Steacy, Lisa M; Evans, Greg; Diamond, Miriam; Sussman, Gordon L; Amistani, Yann; Abiteboul, Kathy; Tenn, Mark W; Yang, ChenXi; Carlsten, Christopher; Conway, Edward M; Mack, Douglas; Othman, Yasmin; Barber, Colin M; Kalicinsky, Chrystyna; Burke, Andrea E; Messieh, Mary; Nair, Parameswaran; Che, Chun T; Douglas, Lindsay; Liem, Joel; Duan, Lucy; Miller, Charlotte; Dupuis, Pascale; Connors, Lori A; Fein, Michael N; Shuster, Joseph; Hadi, Hani; Polk, Brooke; Raje, Nikita; Labrosse, Roxane; Bégin, Philippe; Paradis, Louis; Roches, Anne D; Lacombe-Barrios, Jonathan; Mishra, Sanju; Lacuesta, Gina; Chiasson, Meredith; Haroon, Babar; Robertson, Kara; Issekutz, Thomas; Leddin, Desmond; Couban, Stephen; Connors, Lori; Roos, Adrienne; Kanani, Amin; Chan, Edmond S; Schellenberg, Robert; Rosenfield, Lana; Cvetkovic, Anna; Woodward, Kevin; Quirt, Jaclyn; Watson, Wade T A; Castilho, Edson; Sullivan, Jennifer A; Temple, Beverley; Martin, Donna; Cook, Victoria E; Mills, Christopher; Portales-Casamar, Elodie; Fu, Lisa W; Ho, Alexander; Zaltzman, Jeffrey; Chen, Lucy; Vadas, Peter; Gabrielli, Sofianne; Clarke, Ann; Eisman, Harley; Morris, Judy; Joseph, Lawrence; LaVieille, Sebastien; Ben-Shoshan, Moshe; Graham, François; Barnes, Charles; Portnoy, Jay; Stagg, Vincent; Simons, Elinor; Lefebvre, Diana; Dai, David; Mandhane, Piushkumar; Sears, Malcolm; Tam, Herman; Simons, F. E R; Alotaibi, Dhaifallah; Dawod, Bassel; Tunis, Matthew C; Marshall, Jean; Desjardins, Marylin; Béland, Marianne; Lejtenyi, Duncan; Drolet, Jean-Phillipe; Lemire, Martine; Tsoukas, Christos; Noya, Francisco J; Alizadehfar, Reza; McCusker, Christine T; Mazer, Bruce D; Maestre-Batlle, Danay; Gunawan, Evelyn; Rider, Christopher F; Bølling, Anette K; Pena, Olga M; Suez, Daniel; Melamed, Isaac; Hussain, Iftikhar; Stein, Mark; Gupta, Sudhir; Paris, Kenneth; Fritsch, Sandor; Bourgeois, Christelle; Leibl, Heinz; McCoy, Barbara; Noel, Martin; Yel, Leman; Scott, Ori; Reid, Brenda; Atkinson, Adelle; Kim, Vy H; Roifman, Chaim M; Grunebaum, Eyal; AlSelahi, Eiman; Aleman, Fernando; Oberle, Amber; Trus, Mike; Sussman, Gordon; Kanani, Amin S; Chambenoi, Olivier; Chiva-Razavi, Sima; Grodecki, Savannah; Joshi, Nikhil; Menikefs, Peter; Holt, David; Pun, Teresa; Tworek, Damian; Hanna, Raphael; Heroux, Delia; Rosenberg, Elli; Stiemsma, Leah; Turvey, Stuart; Denburg, Judah; Mill, Christopher; Teoh, Timothy; Zimmer, Preeti; Avinashi, Vishal; Paina, Mihaela; Darwish Hassan, Ahmed A; Oliveria, John P; Olesovsky, Chris; Gauvreau, Gail; Pedder, Linda; Keith, Paul K; Plunkett, Greg; Bolner, Michelle; Pourshahnazari, Persia; Stark, Donald; Vostretsova, Kateryna; Moses, Andrew; Wakeman, Andrew; Singer, Alexander; Gerstner, Thomas; Abrams, Elissa; Johnson, Sara F; Woodgate, Roberta L
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    Effects of a Short Course of Inhaled Corticosteroids in Noneosinophilic Asthmatic Subjects
    (2011-01-01) Lemière, Catherine; Tremblay, Caroline; FitzGerald, Mark; Aaron, Shawn D; Leigh, Richard; Boulet, Louis-Philippe; Martin, James G; Nair, Parameswaran; Olivenstein, Ronald; Chaboillez, Simone
    BACKGROUND: Noneosinophilic asthma has been regarded as a distinct phenotype characterized by a poor response to inhaled corticosteroids (ICS).OBJECTIVE: To determine whether noneosinophilic, steroid-naive asthmatic subjects show an improvement in asthma control, asthma symptoms and spirometry after four weeks of treatment with ICS, and whether they further benefit from the addition of a long-acting beta-2 agonists to ICS.METHODS: A randomized, double-blind, placebo-controlled, multicentre study comparing the efficacy of placebo versus inhaled fluticasone propionate 250 μg twice daily for four weeks in mildly uncontrolled, steroid-naive asthmatic subjects with a sputum eosinophil count ≤2%. This was followed by an open-label, four-week treatment period with fluticasone propionate 250 μg/salmeterol 50 μg, twice daily for all subjects.RESULTS: After four weeks of double-blind treatment, there was a statistically significant and clinically relevant improvement in the mean (± SD) Asthma Control Questionnaire score in the ICS-treated group (n=6) (decrease of 1.0±0.5) compared with the placebo group (n=6) (decrease of 0.09±0.4) (P=0.008). Forced expiratory volume in 1 s declined in the placebo group (−0.2±0.2 L) and did not change in the ICS group (0.04±0.1 L) after four weeks of treatment (P=0.02). The open-label treatment with fluticasone propionate 250 μg/salmeterol 50 μg did not produce additional improvements in those who were previously treated for four weeks with inhaled fluticasone alone.CONCLUSION: A clinically important and statistically significant response to ICS was observed in mildly uncontrolled noneosinophilic asthmatic subjects.
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    Omalizumab in patients with severe asthma and persistent sputum eosinophilia
    (2019-04-03) Mukherjee, Manali; Kjarsgaard, Melanie; Radford, Katherine; Huang, Chynna; Leigh, Richard; Dorscheid, Delbert R; Lemiere, Catherine; Boulet, Louis-Philippe; Waserman, Susan; Martin, James; Nair, Parameswaran
    Abstract Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who remain uncontrolled despite high dose inhaled corticosteroid and bronchodilators. Steroid-sparing effect of omalizumab has not been demonstrated in asthmatics with persistent airway eosinophilia in a randomised controlled trial till date. From this double-blind, placebo-controlled, multi-centred, randomized parallel group design, we report that omalizumab is possibly inadequate to control sputum eosinophilia, and therefore may not have a steroid-sparing effect, especially in those maintained on oral corticosteroids daily. This needs to be confirmed or refuted in a larger trial, which may be a challenge with respect to recruitment, since there are currently three additional biologics available to prescribe. Trial registration Clinicaltrials.gov, NCT02049294, Registered 30th January 2014, https://clinicaltrials.gov/ct2/show/NCT02049294