Browsing by Author "Randall, Alyssa"

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    Ischemia-Reperfusion Arrhythmias and Intercellular Coupling in Diabetic and Ischemic-Preconditioned Rat Heart
    (2013-01-30) Randall, Alyssa; Nygren, Anders
    Diabetes and Ischemic Preconditioning (IPC) have been shown in literature to have similar metabolic and microscopic effects on intercellular coupling, conduction reserve, and the response to ischemia-reperfusion in ventricular tissue. Both diabetes and IPC cause reduced intercellular coupling; reduced conduction reserve; and provide cardio-protection to ischemia/reperfusion. To determine the whole heart similarities between IPC and diabetes both electrocardiograph (ECG) and optical mapping data was evaluated. Diabetes displayed different time dependent responses to ischemia/reperfusion from IPC and healthy animals; diabetic animals slow heart rate significantly compared to IPC and control animals during ischemia, while IPC slows conduction velocity. During pacing, IPC and diabetic animals showed similar slowing of conduction velocity though only diabetic animals showed significant slowing in response to reduced cellular excitability. This work suggests IPC and diabetes do not use the same mechanisms to provide cardio-protective effects.