Browsing by Author "Riabowol, Karl Thomas"

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    Characterizing small ubiquitin like modification of ING1
    (2013-01-23) Satpathy, Shankha; Riabowol, Karl Thomas
    The INhibitor of Growth (ING) proteins have been classified as type II tumor suppressors, being frequently reported to mis-localize or be repressed in several forms of cancer. The ING family consists of 5 genes (ing1-5) encoding multiple protein isoforms. The most conserved domain found in the INGs is the Plant Homeo Domain (PHD) that is commonly found in chromatin remodeling proteins. ING1 and ING2 are a part of the Sin3A-HDAC1/2 protein complex and ING3, ING4, ING5 associate with different HAT complexes. Based upon comprehensive interactome analyses, the 3 yeast ING proteins are predicted to specifically associate with >1,000 yeast proteins. Many recent reports suggest roles for ING proteins in DNA damage repair, apoptosis, chromatin remodeling, angiogenesis, metastasis and senescence, however how the proteins themselves are regulated by various post translational modifications is not yet clear. We have identified a novel post-translational modification of ING1 and altogether our data suggests the role of this modification in ING1 mediated gene regulation.