Browsing by Author "Sawyer, Robert G."

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    Intra-abdominal infections survival guide: a position statement by the Global Alliance For Infections In Surgery
    (2024-06-08) Sartelli, Massimo; Barie, Philip; Agnoletti, Vanni; Al-Hasan, Majdi N.; Ansaloni, Luca; Biffl, Walter; Buonomo, Luis; Blot, Stijn; Cheadle, William G.; Coimbra, Raul; De Simone, Belinda; Duane, Therese M.; Fugazzola, Paola; Giamarellou, Helen; Hardcastle, Timothy C.; Hecker, Andreas; Inaba, Kenji; Kirkpatrick, Andrew W.; Labricciosa, Francesco M.; Leone, Marc; Martin-Loeches, Ignacio; Maier, Ronald V.; Marwah, Sanjay; Maves, Ryan C.; Mingoli, Andrea; Montravers, Philippe; Ordóñez, Carlos A.; Palmieri, Miriam; Podda, Mauro; Rello, Jordi; Sawyer, Robert G.; Sganga, Gabriele; Tattevin, Pierre; Thapaliya, Dipendra; Tessier, Jeffrey; Tolonen, Matti; Ulrych, Jan; Vallicelli, Carlo; Watkins, Richard R.; Catena, Fausto; Coccolini, Federico
    Abstract Intra-abdominal infections (IAIs) are an important cause of morbidity and mortality in hospital settings worldwide. The cornerstones of IAI management include rapid, accurate diagnostics; timely, adequate source control; appropriate, short-duration antimicrobial therapy administered according to the principles of pharmacokinetics/pharmacodynamics and antimicrobial stewardship; and hemodynamic and organ functional support with intravenous fluid and adjunctive vasopressor agents for critical illness (sepsis/organ dysfunction or septic shock after correction of hypovolemia). In patients with IAIs, a personalized approach is crucial to optimize outcomes and should be based on multiple aspects that require careful clinical assessment. The anatomic extent of infection, the presumed pathogens involved and risk factors for antimicrobial resistance, the origin and extent of the infection, the patient’s clinical condition, and the host’s immune status should be assessed continuously to optimize the management of patients with complicated IAIs.
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    The ChoCO-W prospective observational global study: Does COVID-19 increase gangrenous cholecystitis?
    (2022-12-16) De Simone, Belinda; Abu-Zidan, Fikri M.; Chouillard, Elie; Di Saverio, Salomone; Sartelli, Massimo; Podda, Mauro; Gomes, Carlos A.; Moore, Ernest E.; Moug, Susan J.; Ansaloni, Luca; Kluger, Yoram; Coccolini, Federico; Landaluce-Olavarria, Aitor; Estraviz-Mateos, Begoña; Uriguen-Etxeberria, Ana; Giordano, Alessio; Luna, Alfonso P.; Amín, Luz A. H.; Hernández, Adriana M. P.; Shabana, Amanda; Dzulkarnaen, Zakaria A.; Othman, Muhammad A.; Sani, Mohamad I.; Balla, Andrea; Scaramuzzo, Rosa; Lepiane, Pasquale; Bottari, Andrea; Staderini, Fabio; Cianchi, Fabio; Cavallaro, Andrea; Zanghì, Antonio; Cappellani, Alessandro; Campagnacci, Roberto; Maurizi, Angela; Martinotti, Mario; Ruggieri, Annamaria; Jusoh, Asri C.; Rahman, Karim A.; Zulkifli, Anis S. M.; Petronio, Barbara; Matías-García, Belén; Quiroga-Valcárcel, Ana; Mendoza-Moreno, Fernando; Atanasov, Boyko; Campanile, Fabio C.; Vecchioni, Ilaria; Cardinali, Luca; Travaglini, Grazia; Sebastiani, Elisa; Chooklin, Serge; Chuklin, Serhii; Cianci, Pasquale; Restini, Enrico; Capuzzolo, Sabino; Currò, Giuseppe; Filippo, Rosalinda; Rispoli, Michele; Aparicio-Sánchez, Daniel; Muñóz-Cruzado, Virginia D.; Barbeito, Sandra D.; Delibegovic, Samir; Kesetovic, Amar; Sasia, Diego; Borghi, Felice; Giraudo, Giorgio; Visconti, Diego; Doria, Emanuele; Santarelli, Mauro; Luppi, Davide; Bonilauri, Stefano; Grossi, Ugo; Zanus, Giacomo; Sartori, Alberto; Piatto, Giacomo; De Luca, Maurizio; Vita, Domenico; Conti, Luigi; Capelli, Patrizio; Cattaneo, Gaetano M.; Marinis, Athanasios; Vederaki, Styliani-Aikaterini; Bayrak, Mehmet; Altıntas, Yasemin; Uzunoglu, Mustafa Y.; Demirbas, Iskender E.; Altinel, Yuksel; Meric, Serhat; Aktimur, Yunus E.; Uymaz, Derya S.; Omarov, Nail; Azamat, Ibrahim; Lostoridis, Eftychios; Nagorni, Eleni-Aikaterini; Pujante, Antonio; Anania, Gabriele; Bombardini, Cristina; Bagolini, Francesco; Gonullu, Emre; Mantoglu, Baris; Capoglu, Recayi; Cappato, Stefano; Muzio, Elena; Colak, Elif; Polat, Suleyman; Koylu, Zehra A.; Altintoprak, Fatih; Bayhan, Zülfü; Akin, Emrah; Andolfi, Enrico; Rezart, Sulce; Kim, Jae I.; Jung, Sung W.; Shin, Yong C.; Enciu, Octavian; Toma, Elena A.; Medas, Fabio; Canu, Gian L.; Cappellacci, Federico; D’Acapito, Fabrizio; Ercolani, Giorgio; Solaini, Leonardo; Roscio, Francesco; Clerici, Federico; Gelmini, Roberta; Serra, Francesco; Rossi, Elena G.; Fleres, Francesco; Clarizia, Guglielmo; Spolini, Alessandro; Ferrara, Francesco; Nita, Gabriela; Sarnari, Jlenia; Gachabayov, Mahir; Abdullaev, Abakar; Poillucci, Gaetano; Palini, Gian M.; Veneroni, Simone; Garulli, Gianluca; Piccoli, Micaela; Pattacini, Gianmaria C.; Pecchini, Francesca; Argenio, Giulio; Armellino, Mariano F.; Brisinda, Giuseppe; Tedesco, Silvia; Fransvea, Pietro; Ietto, Giuseppe; Franchi, Caterina; Carcano, Giulio; Martines, Gennaro; Trigiante, Giuseppe; Negro, Giulia; Vega, Gustavo M.; González, Agustín R.; Ojeda, Leonardo; Piccolo, Gaetano; Bondurri, Andrea; Maffioli, Anna; Guerci, Claudio; Sin, Boo H.; Zuhdi, Zamri; Azman, Azlanudin; Mousa, Hussam; al Bahri, Shadi; Augustin, Goran; Romic, Ivan; Moric, Trpimir; Nikolopoulos, Ioannis; Andreuccetti, Jacopo; Pignata, Giusto; D’Alessio, Rossella; Kenig, Jakub; Skorus, Urszula; Fraga, Gustavo P.; Hirano, Elcio S.; de Lima Bertuol, Jackson V.; Isik, Arda; Kurnaz, Eray; Asghar, Mohammad S.; Afzal, Ameer; Akbar, Ali; Nikolouzakis, Taxiarchis K.; Lasithiotakis, Konstantinos; Chrysos, Emmanuel; Das, Koray; Özer, Nazmi; Seker, Ahmet; Ibrahim, Mohamed; Hamid, Hytham K. S.; Babiker, Ahmed; Bouliaris, Konstantinos; Koukoulis, George; Kolla, Chrysoula-Christina; Lucchi, Andrea; Agostinelli, Laura; Taddei, Antonio; Fortuna, Laura; Agostini, Carlotta; Licari, Leo; Viola, Simona; Callari, Cosimo; Laface, Letizia; Abate, Emmanuele; Casati, Massimiliano; Anastasi, Alessandro; Canonico, Giuseppe; Gabellini, Linda; Tosi, Lorenzo; Guariniello, Anna; Zanzi, Federico; Bains, Lovenish; Sydorchuk, Larysa; Iftoda, Oksana; Sydorchuk, Andrii; Malerba, Michele; Costanzo, Federico; Galleano, Raffaele; Monteleone, Michela; Costanzi, Andrea; Riva, Carlo; Walędziak, Maciej; Kwiatkowski, Andrzej; Czyżykowski, Łukasz; Major, Piotr; Strzałka, Marcin; Matyja, Maciej; Natkaniec, Michal; Valenti, Maria R.; Di Vita, Maria D. P.; Sotiropoulou, Maria; Kapiris, Stylianos; Massalou, Damien; Veroux, Massimiliano; Volpicelli, Alessio; Gioco, Rossella; Uccelli, Matteo; Bonaldi, Marta; Olmi, Stefano; Nardi, Matteo; Livadoti, Giada; Mesina, Cristian; Dumitrescu, Theodor V.; Ciorbagiu, Mihai C.; Ammendola, Michele; Ammerata, Giorgio; Romano, Roberto; Slavchev, Mihail; Misiakos, Evangelos P.; Pikoulis, Emmanouil; Papaconstantinou, Dimitrios; Elbahnasawy, Mohamed; Abdel-elsalam, Sherief; Felsenreich, Daniel M.; Jedamzik, Julia; Michalopoulos, Nikolaos V.; Sidiropoulos, Theodoros A.; Papadoliopoulou, Maria; Cillara, Nicola; Deserra, Antonello; Cannavera, Alessandro; Negoi, Ionuţ; Schizas, Dimitrios; Syllaios, Athanasios; Vagios, Ilias; Gourgiotis, Stavros; Dai, Nick; Gurung, Rekha; Norrey, Marcus; Pesce, Antonio; Feo, Carlo V.; Fabbri, Nicolo’; Machairas, Nikolaos; Dorovinis, Panagiotis; Keramida, Myrto D.; Mulita, Francesk; Verras, Georgios I.; Vailas, Michail; Yalkin, Omer; Iflazoglu, Nidal; Yigit, Direnc; Baraket, Oussama; Ayed, Karim; Ghalloussi, Mohamed h.; Patias, Parmenion; Ntokos, Georgios; Rahim, Razrim; Bala, Miklosh; Kedar, Asaf; Sawyer, Robert G.; Trinh, Anna; Miller, Kelsey; Sydorchuk, Ruslan; Knut, Ruslan; Plehutsa, Oleksandr; Liman, Rumeysa K.; Ozkan, Zeynep; Kader, Saleh A.; Gupta, Sanjay; Gureh, Monika; Saeidi, Sara; Aliakbarian, Mohsen; Dalili, Amin; Shoko, Tomohisa; Kojima, Mitsuaki; Nakamoto, Raira; Atici, Semra D.; Tuncer, Gizem K.; Kaya, Tayfun; Delis, Spiros G.; Rossi, Stefano; Picardi, Biagio; del Monte, Simone R.; Triantafyllou, Tania; Theodorou, Dimitrios; Pintar, Tadeja; Salobir, Jure; Manatakis, Dimitrios K.; Tasis, Nikolaos; Acheimastos, Vasileios; Ioannidis, Orestis; Loutzidou, Lydia; Symeonidis, Savvas; de Sá, Tiago C.; Rocha, Mónica; Guagni, Tommaso; Pantalone, Desiré; Maltinti, Gherardo; Khokha, Vladimir; Abdel-elsalam, Wafaa; Ghoneim, Basma; López-Ruiz, José A.; Kara, Yasin; Zainudin, Syaza; Hayati, Firdaus; Azizan, Nornazirah; Khei, Victoria T. P.; Yi, Rebecca C. X.; Sellappan, Harivinthan; Demetrashvili, Zaza; Lekiashvili, Nika; Tvaladze, Ana; Froiio, Caterina; Bernardi, Daniele; Bonavina, Luigi; Gil-Olarte, Angeles; Grassia, Sebastiano; Romero-Vargas, Estela; Bianco, Francesco; Gumbs, Andrew A.; Dogjani, Agron; Agresta, Ferdinando; Litvin, Andrey; Balogh, Zsolt J.; Gendrikson, George; Martino, Costanza; Damaskos, Dimitrios; Pararas, Nikolaos; Kirkpatrick, Andrew; Kurtenkov, Mikhail; Gomes, Felipe C.; Pisanu, Adolfo; Nardello, Oreste; Gambarini, Fabrizio; Aref, Hager; Angelis, Nicola d.; Agnoletti, Vanni; Biondi, Antonio; Vacante, Marco; Griggio, Giulia; Tutino, Roberta; Massani, Marco; Bisetto, Giovanni; Occhionorelli, Savino; Andreotti, Dario; Lacavalla, Domenico; Biffl, Walter L.; Catena, Fausto
    Abstract Background The incidence of the highly morbid and potentially lethal gangrenous cholecystitis was reportedly increased during the COVID-19 pandemic. The aim of the ChoCO-W study was to compare the clinical findings and outcomes of acute cholecystitis in patients who had COVID-19 disease with those who did not. Methods Data were prospectively collected over 6 months (October 1, 2020, to April 30, 2021) with 1-month follow-up. In October 2020, Delta variant of SARS CoV-2 was isolated for the first time. Demographic and clinical data were analyzed and reported according to the STROBE guidelines. Baseline characteristics and clinical outcomes of patients who had COVID-19 were compared with those who did not. Results A total of 2893 patients, from 42 countries, 218 centers, involved, with a median age of 61.3 (SD: 17.39) years were prospectively enrolled in this study; 1481 (51%) patients were males. One hundred and eighty (6.9%) patients were COVID-19 positive, while 2412 (93.1%) were negative. Concomitant preexisting diseases including cardiovascular diseases (p < 0.0001), diabetes (p < 0.0001), and severe chronic obstructive airway disease (p = 0.005) were significantly more frequent in the COVID-19 group. Markers of sepsis severity including ARDS (p < 0.0001), PIPAS score (p < 0.0001), WSES sepsis score (p < 0.0001), qSOFA (p < 0.0001), and Tokyo classification of severity of acute cholecystitis (p < 0.0001) were significantly higher in the COVID-19 group. The COVID-19 group had significantly higher postoperative complications (32.2% compared with 11.7%, p < 0.0001), longer mean hospital stay (13.21 compared with 6.51 days, p < 0.0001), and mortality rate (13.4% compared with 1.7%, p < 0.0001). The incidence of gangrenous cholecystitis was doubled in the COVID-19 group (40.7% compared with 22.3%). The mean wall thickness of the gallbladder was significantly higher in the COVID-19 group [6.32 (SD: 2.44) mm compared with 5.4 (SD: 3.45) mm; p < 0.0001]. Conclusions The incidence of gangrenous cholecystitis is higher in COVID patients compared with non-COVID patients admitted to the emergency department with acute cholecystitis. Gangrenous cholecystitis in COVID patients is associated with high-grade Clavien-Dindo postoperative complications, longer hospital stay and higher mortality rate. The open cholecystectomy rate is higher in COVID compared with non -COVID patients. It is recommended to delay the surgical treatment in COVID patients, when it is possible, to decrease morbidity and mortality rates. COVID-19 infection and gangrenous cholecystistis are not absolute contraindications to perform laparoscopic cholecystectomy, in a case by case evaluation, in expert hands. Graphical abstract
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    WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections
    (2021-09-25) Sartelli, Massimo; Coccolini, Federico; Kluger, Yoram; Agastra, Ervis; Abu-Zidan, Fikri M.; Abbas, Ashraf E. S.; Ansaloni, Luca; Adesunkanmi, Abdulrashid K.; Atanasov, Boyko; Augustin, Goran; Bala, Miklosh; Baraket, Oussama; Baral, Suman; Biffl, Walter L.; Boermeester, Marja A.; Ceresoli, Marco; Cerutti, Elisabetta; Chiara, Osvaldo; Cicuttin, Enrico; Chiarugi, Massimo; Coimbra, Raul; Colak, Elif; Corsi, Daniela; Cortese, Francesco; Cui, Yunfeng; Damaskos, Dimitris; de’ Angelis, Nicola; Delibegovic, Samir; Demetrashvili, Zaza; De Simone, Belinda; de Jonge, Stijn W.; Dhingra, Sameer; Di Bella, Stefano; Di Marzo, Francesco; Di Saverio, Salomone; Dogjani, Agron; Duane, Therese M.; Enani, Mushira A.; Fugazzola, Paola; Galante, Joseph M.; Gachabayov, Mahir; Ghnnam, Wagih; Gkiokas, George; Gomes, Carlos A.; Griffiths, Ewen A.; Hardcastle, Timothy C.; Hecker, Andreas; Herzog, Torsten; Kabir, Syed M. U.; Karamarkovic, Aleksandar; Khokha, Vladimir; Kim, Peter K.; Kim, Jae I.; Kirkpatrick, Andrew W.; Kong, Victor; Koshy, Renol M.; Kryvoruchko, Igor A.; Inaba, Kenji; Isik, Arda; Iskandar, Katia; Ivatury, Rao; Labricciosa, Francesco M.; Lee, Yeong Y.; Leppäniemi, Ari; Litvin, Andrey; Luppi, Davide; Machain, Gustavo M.; Maier, Ronald V.; Marinis, Athanasios; Marmorale, Cristina; Marwah, Sanjay; Mesina, Cristian; Moore, Ernest E.; Moore, Frederick A.; Negoi, Ionut; Olaoye, Iyiade; Ordoñez, Carlos A.; Ouadii, Mouaqit; Peitzman, Andrew B.; Perrone, Gennaro; Pikoulis, Manos; Pintar, Tadeja; Pipitone, Giuseppe; Podda, Mauro; Raşa, Kemal; Ribeiro, Julival; Rodrigues, Gabriel; Rubio-Perez, Ines; Sall, Ibrahima; Sato, Norio; Sawyer, Robert G.; Segovia Lohse, Helmut; Sganga, Gabriele; Shelat, Vishal G.; Stephens, Ian; Sugrue, Michael; Tarasconi, Antonio; Tochie, Joel N.; Tolonen, Matti; Tomadze, Gia; Ulrych, Jan; Vereczkei, Andras; Viaggi, Bruno; Gurioli, Chiara; Casella, Claudio; Pagani, Leonardo; Baiocchi, Gian L.; Catena, Fausto
    Abstract Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in hospitals worldwide. The cornerstones of effective treatment of IAIs include early recognition, adequate source control, appropriate antimicrobial therapy, and prompt physiologic stabilization using a critical care environment, combined with an optimal surgical approach. Together, the World Society of Emergency Surgery (WSES), the Global Alliance for Infections in Surgery (GAIS), the Surgical Infection Society-Europe (SIS-E), the World Surgical Infection Society (WSIS), and the American Association for the Surgery of Trauma (AAST) have jointly completed an international multi-society document in order to facilitate clinical management of patients with IAIs worldwide building evidence-based clinical pathways for the most common IAIs. An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting information was shared by an international task force from 46 countries with different clinical backgrounds. The aim of the document is to promote global standards of care in IAIs providing guidance to clinicians by describing reasonable approaches to the management of IAIs.
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    WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections
    (2022-01-15) Sartelli, Massimo; Coccolini, Federico; Kluger, Yoram; Agastra, Ervis; Abu-Zidan, Fikri M.; Abbas, Ashraf E. S.; Ansaloni, Luca; Adesunkanmi, Abdulrashid K.; Augustin, Goran; Bala, Miklosh; Baraket, Oussama; Biffl, Walter L.; Ceresoli, Marco; Cerutti, Elisabetta; Chiara, Osvaldo; Cicuttin, Enrico; Chiarugi, Massimo; Coimbra, Raul; Corsi, Daniela; Cortese, Francesco; Cui, Yunfeng; Damaskos, Dimitris; de’Angelis, Nicola; Delibegovic, Samir; Demetrashvili, Zaza; De Simone, Belinda; de Jonge, Stijn W.; Di Bella, Stefano; Di Saverio, Salomone; Duane, Therese M.; Fugazzola, Paola; Galante, Joseph M.; Ghnnam, Wagih; Gkiokas, George; Gomes, Carlos A.; Griffiths, Ewen A.; Hardcastle, Timothy C.; Hecker, Andreas; Herzog, Torsten; Karamarkovic, Aleksandar; Khokha, Vladimir; Kim, Peter K.; Kim, Jae I.; Kirkpatrick, Andrew W.; Kong, Victor; Koshy, Renol M.; Inaba, Kenji; Isik, Arda; Ivatury, Rao; Labricciosa, Francesco M.; Lee, Yeong Y.; Leppäniemi, Ari; Litvin, Andrey; Luppi, Davide; Maier, Ronald V.; Marinis, Athanasios; Marwah, Sanjay; Mesina, Cristian; Moore, Ernest E.; Moore, Frederick A.; Negoi, Ionut; Olaoye, Iyiade; Ordoñez, Carlos A.; Ouadii, Mouaqit; Peitzman, Andrew B.; Perrone, Gennaro; Pintar, Tadeja; Pipitone, Giuseppe; Podda, Mauro; Raşa, Kemal; Ribeiro, Julival; Rodrigues, Gabriel; Rubio-Perez, Ines; Sall, Ibrahima; Sato, Norio; Sawyer, Robert G.; Shelat, Vishal G.; Sugrue, Michael; Tarasconi, Antonio; Tolonen, Matti; Viaggi, Bruno; Celotti, Andrea; Casella, Claudio; Pagani, Leonardo; Dhingra, Sameer; Baiocchi, Gian L.; Catena, Fausto
    Abstract Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections. Together, the World Society of Emergency Surgery, the Global Alliance for Infections in Surgery, the Surgical Infection Society-Europe, The World Surgical Infection Society, and the American Association for the Surgery of Trauma have jointly completed an international multi-society document to promote global standards of care in SSTIs guiding clinicians by describing reasonable approaches to the management of SSTIs. An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting evidence was shared by an international task force with different clinical backgrounds.