Browsing by Author "Shariff, Sami"

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    Human Rhinovirus Infection of Airway Epithelial Cells Modulates Airway Smooth Muscle Migration
    (2015-12-22) Shariff, Sami; Leigh, Richard; Proud, David; Kubes, Paul; Giembycz, Mark
    The traditional paradigm of airway remodeling in asthma has held that remodeling occurs after many years of chronic inflammation. However, studies have confirmed that remodeling changes are observed in children even before the clinical diagnosis of asthma is established. There is now robust evidence to indicate that children with recurrent human rhinovirus (HRV)-induced wheezing episodes are at significantly increased risk of developing subsequent asthma. A feature of airway remodeling is increased airway smooth muscle (ASM) mass with a greater proximity of the ASM to the subepithelial region, and we interrogated the hypothesis that HRV-induced alterations of airway epithelial cell biology might regulate ASM migration. We demonstrated that ASM chemotaxis is GPCR dependent, can be regulated by cAMP and is dependent upon CCL5 release by the epithelium post-HRV infection. These observations substantiate the growing body of evidence that links HRV infections to the subsequent development of asthma.