Browsing by Author "Trapp, Bruce D. T."

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    Glutamate receptors on myelinated spinal cord axons: I. GluR6 kainate receptors
    (Wiley-Liss, Inc., 2009-02) Ouardouz, Mohamed; Basak, Ajoy; Chen, Andrew; Rehak, Renata; Yin, Xinghua; Coderre, Elaine M.; Zamponi, Gerald W.; Hameed, Shahid; Trapp, Bruce D. T.; Stys, Peter K.
    The deleterious effects of glutamate excitotoxicity are well described for central nervous system gray matter. Although overactivation of glutamate receptors also contributes to axonal injury, the mechanisms are poorly understood. Our goal was to elucidate the mechanisms of kainate receptor-dependent axonal Ca(2+) deregulation.
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    Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors
    (Wiley-Liss Inc., 2009-02-01) Ouardouz, Mohamed; Hameed, Shameed; Yin, Xinghua; Zamponi, Gerald W.; Coderre, Elaine M.; Trapp, Bruce D. T.; Stys, Peter K.
    Glutamate receptors, which play a major role in the physiology and pathology of central nervous system gray matter, are also involved in the pathophysiology of white matter. However, the cellular and molecular mechanisms responsible for excitotoxic damage to white matter elements are not fully understood. We explored the roles of AMPA and GluR5 kainate receptors in axonal Ca(2+) deregulation.