Browsing by Author "Wallace, John L."
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Item Open Access A mimetic of vascular endothelial growth factor accelerates gastric ulcer healing in rodents(2008) Dudar, Genevieve Katherine; Wallace, John L.Item Open Access Anti-Inflammatory and Cytoprotective Actions of Hydrogen Sulfide: Translation to Therapeutics(Antioxidants & Redox Signaling, 2015-04-15) Wallace, John L.; Blackler, Rory W.; Chan, Melissa V.; Da Silva, Gabriela J.; Elsheikh, Wagdi; Flannigan, Kyle L.; Gamaniek, Iulia; Manko, Anna; Wang, Lu; Motta, Jean-Paul; Buret, Andre G.Significance: There is a rapidly expanding body of evidence for important roles of hydrogen sulfide in protecting against tissue injury, reducing inflammation, and promoting repair. There is also growing evidence that H2S can be successfully exploited in drug development. Recent Advances: H2S synthesis and degradation are regulated in circumstances of inflammation and injury so as to promote repair and re-establish homeostasis. Novel H2S-releasing drugs exhibit enhanced anti-inflammatory and pro-restorative effects, while having reduced adverse effects in many tissues. Critical Issues: H2S is a pleiotropic mediator, having effects on many elements in the inflammatory cascade and promoting the resolution of inflammation and injury. It also contributes significantly to mucosal defence in the gastrointestinal tract, and in host defence against infection. There is strong evidence that novel, H2S-based therapeutics are safe and effective in animal models, and several are progressing through human trials. Future Directions: A better understanding of the physiological and pathophysiological roles of H2S continues to be restrained by the lack of simple, reliable methods for measurement of H2S synthesis, and the paucity of highly selective inhibitors of enzymes that participate in endogenous H2S synthesis. On the other hand, H2S donors show promise as therapeutics for several important indications. Antioxid. Redox Signal. 22, 398–410.Item Open Access Characterization of platelet-activating factor release by rat mast cells and its pharmacological modulation(1993) Hogaboam, Cory Michel; Wallace, John L.Item Open Access Correction: Hydrogen sulfide-releasing cyclooxygenase inhibitor ATB-346 enhances motor function and reduces cortical lesion volume following traumatic brain injury in mice(2024-05-28) Campolo, Michela; Esposito, Emanuela; Ahmad, Akbar; Di Paola, Rosanna; Paterniti, Irene; Cordaro, Marika; Bruschetta, Giuseppe; Wallace, John L.; Cuzzocrea, SalvatoreItem Open Access Efficacy of a Peruvian Botanical Remedy (Sabell A4+) for Treating Liver Disease and Protecting Gastric Mucosal Integrity(2019-10-24) Swain, Mark G.; Wallace, John L.; Tyrrell, D. Lorne; Cabanillas, José; Aung, Steven K. H.; Liu, Hongqun; Finnie-Carvalho, Lindsay; Shrestha, Grishma; Semple, Hugh A.; Green, Francis H. Y.The purpose of this study was to determine the efficacy of a Peruvian botanical formulation for treating disorders of hepatic function and gastric mucosal integrity. The formulation A4+ (Sabell Corporation) contains extracts of Curcuma longa rhizome, Cordia lutea flower, and Annona muricata leaf. Individually these plants have been used as traditional remedies for liver disease. We report the efficacy of A4+ and its components using a variety of in vitro and in vivo disease models. The methods used included tests for antioxidant, anti-inflammatory, and antiviral activity as well as mouse models of liver disease, including Concanavalin A-induced immune-mediated hepatitis and a bile duct ligation model for evaluating sickness behaviour associated with liver disease. Rat models were used to evaluate the gastric mucosal protective property of A4+ following indomethacin challenge and to evaluate its anti-inflammatory action in an “air pouch” model. In all tests, A4+ proved to be more effective than placebo. A4+ was antioxidant and anti-inflammatory and diminished Hepatitis C virus replication in vitro. In animal models, A4+ was shown to protect the liver from immune-mediated hepatitis, improve behavioural function in animals with late stage liver disease, and protect the rat gastric mucosa from ulceration following NSAID exposure. We conclude that A4+ ameliorated many aspects of liver injury, inhibited hepatitis C virus replication, and protected the gastric mucosa from NSAIDs. These varied beneficial properties appear to result from positive interactions between the three constituent herbs.Item Open Access Enhanced anti-inflammatory effects of NCX-1015 in the rat(2002) Turesin, Fusun; Wallace, John L.Item Open Access Factors that modulate gastric ulcer healing(1999) Elliott, Susan Nicole; Wallace, John L.Item Open Access Nitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't so(1995-01-01) Kubes, Paul; Wallace, John L.Nitric oxide has been suggested as a contributor to tissue injury in various experimental models of gastrointestinal inflammation. However, there is overwhelming evidence that nitric oxide is one of the most important mediators of mucosal defence, influencing such factors as mucus secretion, mucosal blood flow, ulcer repair and the activity of a variety of mucosal immunocytes. Nitric oxide has the capacity to down-regulate inflammatory responses in the gastrointestinal tract, to scavenge various free radical species and to protect the mucosa from injury induced by topical irritants. Moreover, questions can be raised regarding the evidence purported to support a role for nitric oxide in producing tissue injury. In this review, we provide an overview of the evidence supporting a role for nitric oxide in protecting the gastrointestinal tract from injury.Item Open Access Pathogenesis of NSAID-induced intestinal toxicity: studies in healthy rats and rats with colitis(1999) Reuter, Brian Karl; Wallace, John L.Item Open Access Regulation of human platelet activity by proteinase-activated receptors (pars)(2008) Parkins, Brent Alan; Wallace, John L.Item Open Access Role of reactive oxygen metabolites and leukotrienes in the pathogenesis of nsaid-gastropathy(1991) Vaananen, Paula; Wallace, John L.Item Open Access The regulation of cycooxygenase-2 and inducible nitric oxide synthase expression in J774.A1 macrophages by nonsteroidal anti-inflammatory drugs and nitric oxide(1996) Tigley, Allan W.; Wallace, John L.Item Open Access The role of mucosal mast cells in injury and defence in the gastrointestinal tract(1996) Rioux, Kevin Paul; Wallace, John L.