Browsing by Author "Walton, Matthew"

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    Brain white matter structure and language ability in preschool-aged children
    (2018-01) Walton, Matthew; Dewey, Deborah; Lebel, Catherine A.
    Brain alterations are associated with reading and language difficulties in older children, but little research has investigated relationships between early language skills and brain white matter structure during the preschool period. We studied 68 children aged 3.0-5.6 years who underwent diffusion tensor imaging and participated in assessments of Phonological Processing and Speeded Naming. Tract-based spatial statistics and tractography revealed relationships between Phonological Processing and diffusion parameters in bilateral ventral white matter pathways and the corpus callosum. Phonological Processing was positively correlated with fractional anisotropy and negatively correlated with mean diffusivity. The relationships observed in left ventral pathways are consistent with studies in older children, and demonstrate that structural markers for language performance are apparent as young as 3 years of age. Our findings in right hemisphere areas that are not as commonly found in adult studies suggest that young children rely on a widespread network for language processing that becomes more specialized with age.
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    Prepartum and Postpartum Maternal Depressive Symptoms Are Related to Children's Brain Structure in Preschool
    (2016-12-01) Lebel, Catherine; Walton, Matthew; Letourneau, Nicole; Giesbrecht, Gerald F; Kaplan, Bonnie J; Dewey, Deborah
    Perinatal maternal depression is a serious health concern with potential lasting negative consequences for children. Prenatal depression is associated with altered brain gray matter in children, though relations between postpartum depression and children's brains and the role of white matter are unclear.