Browsing by Author "Yu, Yang"

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    ItemOpen Access
    13th International Conference on Conservative Management of Spinal Deformities and First Joint Meeting of the International Research Society on Spinal Deformities and the Society on Scoliosis Orthopaedic and Rehabilitation Treatment – SOSORT-IRSSD 2016 meeting
    (2017-05-30) Bagheri, Aria; Liu, Xue-Cheng; Tassone, Channing; Thometz, John; Chaloupka, Amie; Tarima, Sergey; Cohen, Larry; Simic, Milena; Dennis, Sarah; Refshauge, Kathryn; Pappas, Evangelos; Parent, Eric C; Pietrosanu, Matthew; Redford, Emily; Schmidt, Sheri; Hill, Douglas; Moreau, Marc; Hedden, Douglas; Adeeb, Samer; Lou, Edmond; Brink, Rob C; Schlösser, Tom P C; Colo, Dino; Vincken, Koen L; van Stralen, Marijn; Hui, Steve C N; Chu, Winnie C W; Cheng, Jack C Y; Castelein, René M; Kechagias, Vasileios; Grivas, Theodoros B; Vlasis, Konstantinos; Michas, Konstantinos; Grivas, Theodoros B; Kechagias, Vasileios; Vlasis, Konstantinos; Michas, Konstantinos; Tam, Elisa M S; Yu, Fiona W P; Hung, Vivian W Y; Shi, Lin; Qin, Ling; Ng, Bobby K W; Chu, Winnie C W; Griffith, James; Cheng, Jack C Y; Lam, Tsz P; Xue, Cindy; Shi, Lin; Hui, Steve C N; Lam, Tsz P; Ng, Bobby K W; Cheng, Jack C Y; Chu, Winnie C W; Hui, Steve C N; Pialasse, Jean-Philippe; Wong, Judy Y H; Lam, Tsz P; Ng, Bobby K W; Cheng, Jack C Y; Chu, Winnie C W; Vo, Quang N; Le, Lawrence H; Lou, Edmond H M; Zheng, Rui; Hill, Douglas L; Moreau, Marc J; Hedden, Douglas M; Mahood, James K; Southon, Sarah; Lou, Edmond; Brignol, Arnaud; Cheriet, Farida; Miron, Marie-Claude; Laporte, Catherine; Qiu, Yong; Liu, Hao; Liu, Zhen; Zhu, Ze-zhang; Qian, Bang-ping; Liu, XueCheng; Rizza, Robert; Thometz, John; Rosol, Derek; Tassone, Channing; Tarima, Sergey; North, Paula; Zaina, Fabio; Pesenti, Francesca; Negrini, Stefano; Persani, Luca; Capodaglio, Paolo; Polli, Nicoletta; Yip, Benjamin H K; Yu, Fiona W P; Hung, Vivian W Y; Lam, Tsz P; Qin, Ling; Ng, Bobby K W; Cheng, Jack C Y; Zhang, Jiajun; Lee, Wayne Y W; Chen, Huanxiong; Tam, Elisa M S; Man, Gene C; Lam, Tsz P; Ng, Bobby K W; Qiu, Yong; Cheng, Jack C Y; Liu, Hao; Liu, Zhen; Zhu, Zezhang; Qian, Bang P; Qiu, Yong; Harasymczuk, P.; Andrusiewicz, M.; Janusz, P.; Biecek, P.; Kotwicki, T.; Kotwicka, M.; Lee, Jung S; Shin, Jong K; Goh, Tae S; Son, Seung M; Chen, Huanxiong; Lee, Wayne Y W; Zhang, Jiajun; Tam, Elisa M S; Man, Gene C W; Lam, Tsz P; Ng, Bobby K W; Qiu, Yong; Cheng, Jack C Y; Schwartz, Mark; Gilday, Sarah; Bylski-Austrow, Donita I; Glos, David L; Schultz, Lindsay; O’Hara, Sara; Jain, Viral V; Sturm, Peter F; Wang, Xiaoyu; Crandall, Dennis G; Parent, Stefan; Larson, Noelle; Labelle, Hubert; Aubin, Carl-Eric; Fard, Negar B; Southon, Sarah; Moreau, Marc; Hedden, Douglas; Duke, Kajsa; Southon, Sarah; Lukenchuk, Leeann; Kerslake, Matthew; Huynh, Geraldine; Chorney, Jill; Tsui, Ban; Tobert, Daniel; Bakarania, Prachi; Berdishevsky, Hagit; Grimes, Kelly; Matsumoto, Hiroko; Hyman, Joshua; Roye, Benjamin; Roye, David; Vitale, Michael; Black, Jason; Bradley, Michael; Drake, Shawn; Glynn, David; Maude, Erika; Berdishevsky, Hagit; Lindgren, Amelia; Bakarania, Prachi; Grimes, Kelly; Matsumoto, Hiroko; Feinberg, Nicholas; Bloom, Zachary; Roye, David; Vitale, Michael; Dupuis, Sarah; Fortin, Carole; Caouette, Christiane; Aubin, Carl-Éric; Gur, Gozde; Yakut, Yavuz; Jevtić, Nikola; Schreiber, Sanja; Hennes, Axel; Pantović, Milan; de Mauroy, Jean-Claude; Barral, Frédéric; Pourret, Sophie; de Mauroy, Jean-Claude; Barral, Frédéric; Pourret, Sophie; Aulisa, Angelo G; Guzzanti, Vincenzo; Galli, Marco; Falciglia, Francesco; Aulisa, Lorenzo; Bernard, Jean-Claude; Deceuninck, Julie; Berthonnaud, Eric; Rougelot, Adrien; Pickering, Marie-Eva; Chaleat-Valayer, Emmanuelle; Webb, Richard; Bettany-Saltikov, Josette; Neil, Barbara; Zaina, Fabio; Poggio, Martina; Donzelli, Sabrina; Lusini, Monia; Minnella, Salvatore; Negrini, Stefano; de Mauroy, Jean-Claude; Barral, Frédéric; Hoang, Alith; Mao, Saihu; Shi, Benlong; Qian, Bangping; Zhu, Zezhang; Sun, Xu; Qiu, Yong; Cobetto, Nikita; Aubin, Carl-Éric; Parent, Stefan; Barch, Soraya; Turgeon, Isabelle; Labelle, Hubert; Raihan, Hasan M A; Kumar, Datta T; Khasnabis, Chapal; Equbal, Ameed; Chakraborty, Ashis K; Biswas, Abhishek; Gur, Gozde; Dilek, Burcu; Ayhan, Cigdem; Simsek, Engin; Aras, Ozgen; Aksoy, Songul; Yakut, Yavuz; Lou, Edmond; Hill, Doug; Zheng, Rui; Donauer, Andreas; Tilburn, Melissa; Raso, Jim; Morau, Marc; Hedden, Douglas; Chen, He; Man-Sang, Wong; Cohen, Larry; Kobayashi, Sarah; Simic, Milena; Dennis, Sarah; Refshauge, Kathryn; Pappas, Evangelos; Aslanzadeh, Fatemeh; Parent, Eric C; MacIntosh, Brian; Maragkoudakis, Emmanouil G; Grivas, Theodoros B; Gelalis, Ioannis D; Mazioti, Christina; Tsilimidos, Gerasimos; Burwell, R. G; Zheng, Yu; Wu, Xiao-Jun; Dang, Yi-Ni; Sun, Ning; Yang, Yan; Wang, Tao; He, Cheng-Qi; Wong, Man-Sang; Donzelli, Sabrina; Martinez, Gregorio; Negrini, Alberto; Zaina, Fabio; Negrini, Stefano; Matsumoto, Hiroko; Feinberg, Nicholas; Shirley, Matthew; Swindell, Hasani; Bloom, Zachary; Roye, David P; Akbarnia, Behrooz A; Garg, Sumeet; Sanders, James O; Skaggs, David L; Smith, John T; Vitale, Michael G; Rizza, Robert; Liu, XueCheng; Thometz, John; Lou, Edmond; Hill, Doug; Donauer, Andreas; Tilburn, Melissa; Hedden, Douglas; Moreau, Marc; Healy, Aoife; Farmer, Sybil; Chockalingam, Nachiappan; Aulisa, Angelo G; Guzzanti, Vincenzo; Galli, Marco; Pizzetti, Paolo; Aulisa, Lorenzo; Maruyama, Toru; Kobayashi, Yosuke; Nakao, Yusuke; Liu, Hao; Qian, Bang P; Qiu, Yong; Mao, Sai-hu; Wang, Bin; Yu, Yang; Zhu, Zezhang; Berdishevsky, Hagit; Lindgren, Amelia M; Bakarania, Prachi; Grimes, Kelly; Makhni, Melvin C; Shillingford, Jamal; Vitale, Michael G; Black, Jason; Maude, Erika; Turland, Abbie; Glynn, David; Caronni, Antonio; Sciumè, Luciana; Donzelli, Sabrina; Zaina, Fabio; Negrini, Stefano; Schreiber, Sanja; Parent, Eric C; Moez, Elham K; Hedden, Douglas M; Hill, Douglas L; Moreau, Marc; Lou, Edmond; Watkins, Elise M; Southon, Sarah C; Parent, Eric C; Schreiber, Sanja; Moez, Elham K; Sloan, Preston; Hedden, Douglass; Moreau, Marc; Hill, Douglas; Southon, Sarah; Watkins, Elise; Parent, Eric C; Ghaneei, Maliheh; Adeeb, Samer; Schreiber, Sanja; Moreau, Marc; Hedden, Douglas; Hill, Douglas; Southon, Sarah; Karavidas, Nikos; Dritsa, Despoina; Bettany-Saltikov, Josette; Hanchard, Nigel; Kim, Donghyun; Kim, Junlae; Sbihli, Amy; Parent, Eric; Levey, Lauren; Holowka, Mark; Davis, Leigh; Dolan, Lori A; Weinstein, Stuart L; Larson, Jill E; Meyer, Maximilian A; Boody, Barrett; Sarwark, John F; Schreiber, Sanja; Parent, Eric C; Hedden, Douglas M; Hill, Douglas L; Thometz, John; Liu, XueCheng; Rizza, Robert; Tassone, Channing; Liu, XueCheng; Gundlach, Benjamin; Tarima, Sergey; Grant, Alison; Kalyan, Raman; Hekal, Waleed; Honeyman, Cheryl; Cook, Tim; Murray, Scott; Pitruzzella, Morena; Donzelli, Sabrina; Zaina, Fabio; Negrini, Stefano; de Mauroy, Jean-Claude; Barral, Frédéric; Pourret, Sophie; de Mauroy, Jean-Claude; Barral, Frédéric; Pourret, Sophie; Grimes, Kelly; Feinberg, Nicholas; Hope, Jennifer; Berdishevsky, Hagit; Bakarania, Prachi; Matsumoto, Hiroko; Swindell, Hasani; Yoshimachi, Julie; Roye, David; Vitale, Michael; Touchette, Julie; St-Jean, Anissa; Brousseau, Danica; Marcotte, Louise; Théroux, Jean; Doucet, Chantal; Lin, Yangmin; Wong, Man S; MacMahon, John; MacMahon, Edward; Boyette, Jeremy; Stikeleather, Luke; Lebel, Andrea; Lebel, Victoria A; Pancholi-Parekh, Chintan A; Stolze, Lise; Selthafner, Marissa; Hong, Kaitlin; Liu, XueCheng; Thometz, John; Tassone, Channing; Morrison, Pamela R; Hanke, Timothy A; Knott, Patrick; Krumdick, Nathaniel D; Chockalingam, Nachiappan; Shannon, Thomas; Davenhill, Ryan; Needham, Robert; Jasani, Vinay; Ahmed, El-Nasri; St-Jean, Anissa; Touchette, Julie; Drake, Shawn; Brousseau, Danica; Marcotte, Louise; Théroux, Jean; Doucet, Chantal; Aulisa, Angelo G; Guzzanti, Vincenzo; Gordano, Marco; Mastantuoni, Giuseppe; Aulisa, Lorenzo; Chandrinos, Michail; Grivas, Theodoros B; Kechagias, Vasileios; Głowka, Paweł; Gaweł, Dominik; Kasprzak, Bartosz; Nowak, Michał; Morzyński, Marek; Kotwicki, Tomasz; Deceuninck, Julie; Bernard, Jean-Claude; Lecante, Cyril; Berthonnaud, Eric; Fortin, Carole; Aubin-Fournier, Jean-François; Bettany-Saltikov, Josette; Parent, Eric C; Feldman, Debbie E; Bernard, Jean-Claude; Liu, Zhen; Zhang, Wen; Hu, Zongshan; Zhu, Weiguo; Jin, Mengran; Han, Xiao; Qiu, Yong; Cheng, Jack C Y; Zhu, Zezhang; Liu, Zhen; Guo, Jing; Wu, Tao; Qian, Bangping; Zhu, Zezhang; Zhu, Feng; Jiang, Jian; Qiu, Yong; Han, Xiao; Liu, Zhen; Liu, Hao; Qiu, Yong; Guo, Jing; Yan, Huang; Sun, Xu; Cheng, Jack C Y; Zhu, Zezhang; Di Felice, Francesca; Zaina, Fabio; Pitruzzella, Morena; Donzelli, Sabrina; Negrini, Stefano; Needham, Robert A; Chatzistergos, Panagiotis; Chockalingam, Nachiappan; Brink, Rob C; Schlösser, Tom P C; Colo, Dino; Vincken, Koen L; van Stralen, Marijn; Hui, Steve C N; Chu, Winnie C W; Cheng, Jack C Y; Castelein, René M; Bylski-Austrow, Donita I; Glos, David L; Jain, Viral V; Reynolds, Joseph E; Sturm, Peter F; Wall, Eric J; Igoumenou, Vasilios G; Megaloikonomos, Panayiotis D; Tsiavos, Konstantinos; Panagopoulos, Georgios N; Mavrogenis, Andreas F; Grivas, Theodoros B; Soultanis, Konstantinos; Papagelopoulos, Panayiotis J; Fard, Negar B; Duke, Kajsa; Chan, Andrew; Parent, Eric C; Lou, Edmond; Lee, Jung S; Shin, Jong K; Goh, Tae S; Son, Seung M; Kobayashi, Sho; Togawa, Daisuke; Hasegawa, Tomohiko; Yamato, Yu; Oe, Shin; Banno, Tomohiro; Mihara, Yuuki; Matsuyama, Yukihiro
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    ItemOpen Access
    Explainable Autoencoder Deciphering Key Pathways Underlying Cancer Expression Patterns
    (2021-09) Yu, Yang; Liao, Wenyuan; Zhang, Qingrun; Thierry Chekouo, Tekougang; Xuewen, Lu
    Modern machine learning methods have been extensively utilized in gene expression data analysis. In particular, autoencoders (AE) have been employed in processing noisy and heterogenous RNA-Seq data. However, AEs usually lead to “black-box” hidden variables difficult to interpret, hindering downstream experimental validations and clinical translation. To bridge the gap between complicat-ed models and the biological interpretations, we developed a tool, XAE4Exp (eXplainable AutoEn-coder for Expression data), which integrates AE and SHapley Additive exPlanations (SHAP), a flagship technique in the field of eXplainable AI (XAI). It quantitatively evaluates the contributions of each gene to the hidden structure learned by an AE, substantially improving the expandability of AE outcomes. By applying XAE4Exp to The Cancer Genome Atlas (TCGA) breast cancer gene ex-pression data, we revealed intriguing pathways including cell damage management, cell cycle, immune system related pathways underlying breast cancer. This tool will enable researchers and practitioners to analyze high-dimensional expression data intuitively, paving the way towards broad-er uses of deep learning.
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    ItemOpen Access
    Microscale Tissue Engineering for the Study and Treatment of Diabetes
    (2018-12-12) Yu, Yang; Ungrin, Mark D.; Huang, Carol T. L.; Rancourt, Derrick E.
    Islet transplantation is a promising approach to the treatment of insulin-dependent diabetes. However, a major clinical challenge is inefficient survival and engraftment of the transplanted material. This has been associated with insufficient oxygen and nutrition delivery after loss of the endogenous capillaries, and stress induced during islet isolation and culture. Quantitative modelling of oxygen delivery predicts significant advantages for smaller islets, and consistent with this concept, smaller human islets have also performed better than larger ones in clinical settings. In order to understand and overcome these limitations for both research and clinical applications, we have established a microscale tissue engineering approach that is capable of consistently and efficiently generating size-controlled pseudoislets from human donor islets, yielding improved survival and function both in vitro and in vivo. We then combined this platform with advanced statistical methodologies and laboratory automation systems to enable assessment of large numbers of modifying factors (and their interactions) identified from the literature in parallel. This project has yielded a substantial improvement in the consistency and efficacy of islet cell packaging for transplantation, and laid a foundation for rapid transition to the clinic.