Browsing by Author "Zhang, Jianguo"

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    Association between routine and standardized blood pressure measurements and left ventricular hypertrophy among patients on hemodialysis
    (BioMed Central, 2010-06-24) Khangura, Jaspreet; Culleton, Bruce F.; Manns, Braden J.; Zhang, Jianguo; Barnieh, Lianne; Walsh, Michael; Klarenbach, Scott W.; Tonelli, Marcello; Sarna, Magdalena; Hemmelgarn, Brenda R.
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    Association of vitamin D status with socio-demographic factors in Calgary, Alberta: an ecological study using Census Canada data
    (BioMed Central, 2013-04-08) Naugler, Christopher T.; Zhang, Jianguo; Henne, Dan; Woods, Paul; Hemmelgarn, Brenda R
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    Derivation and internal validation of an equation for albumin-adjusted calcium
    (BioMed Central, 2008) James, Matthew T.; Zhang, Jianguo; Lyon, Andrew W; Hemmelgarn, Brenda R
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    Evaluation of an electronic warfarin nomogram for anticoagulation of hemodialysis patients
    (BioMed Central, 2011-09-26) Thomson, Benjamin K. A.; MacRae, Jennifer M.; Barnieh, Lianne; Zhang, Jianguo; MacKay, Elizabeth; Manning, Megan A.; Hemmelgarn, Brenda R.
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    Regional variation in the potentially inappropriate first-line use of fluoroquinolones in Canada as a key to antibiotic stewardship? A drug utilization review study
    (2021-08-03) St-Jean, Audray; Chateau, Dan; Dahl, Matthew; Ernst, Pierre; Daneman, Nick; Sketris, Ingrid S.; Zhang, Jianguo; Marra, Fawziah; Quail, Jacqueline; Bugden, Shawn
    Abstract Background Serious adverse effects of fluoroquinolone antibiotics have been described for more than decade. Recently, several drug regulatory agencies have advised restricting their use in milder infections for which other treatments are available, given the potential for disabling and possibly persistent side effects. We aimed to describe variations in fluoroquinolone use for initial treatment of urinary tract infection (UTI), acute bacterial sinusitis (ABS), and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in the outpatient setting across Canada. Methods Using administrative health data from six provinces, we identified ambulatory visits with a diagnosis of uncomplicated UTI, uncomplicated AECOPD or ABS. Antibiotic exposure was determined by the first antibiotic dispensed within 5 days of the visit. Results We identified 4,303,144 uncomplicated UTI events among 2,170,027 women; the proportion of events treated with fluoroquinolones, mostly ciprofloxacin, varied across provinces, ranging from 18.6% (Saskatchewan) to 51.6% (Alberta). Among 3,467,678 ABS events (2,087,934 patients), between 2.2% (Nova Scotia) and 11.2% (Ontario) were dispensed a fluoroquinolone. For 1,319,128 AECOPD events among 598,347 patients, fluoroquinolones, mostly levofloxacin and moxifloxacin, ranged from 5.8% (Nova Scotia) to 35.6% (Ontario). The proportion of uncomplicated UTI and ABS events treated with fluoroquinolones declined over time, whereas it remained relatively stable for AECOPD. Conclusions Fluoroquinolones were commonly used as first-line therapies for uncomplicated UTI and AECOPD. However, their use varied widely across provinces. Drug insurance formulary criteria and enforcement may be a key to facilitating better antibiotic stewardship and limiting potentially inappropriate first-line use of fluoroquinolones.
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    The Association Between Income and Patient-Reported Diabetes Care: Results of a Cross-Sectional Survey
    (2016) Saad, Nathalie; Hemmelgarn, Brenda; McBrien, Kerry; Edwards, Alun; Zhang, Jianguo
    The main objective of this study was to evaluate the association between income and indicators of access to care as well as indicators of guideline-concordant recommended care in patients with diabetes and poor glycemic control. We used data from a cross-sectional telephone survey of outpatients with diabetes and linked this data with administrative and laboratory data. The study population included adult outpatients living in Calgary, Alberta with diabetes. The exposure was the total household income in the prior 12 months, as reported by survey respondents. We conducted a poisson regression analysis to determine the association between income and each of the outcome variables. We found that participants with an annual household income of < $20,000 were less likely to report taking recommended aspirin as well as statin therapy compared to those with an annual household income > $50,000. Further research is required to delineate the underlying reasons for these results.