Temporal profile of blood cytokine levels and placental pathology in extremely preterm infants

Simple item page
dc.contributor.advisorEsser, Michael J.
dc.contributor.authorZein, Hussein
dc.contributor.committeememberBründler, Marie Anne
dc.contributor.committeememberKirton, Adam
dc.contributor.committeememberMohammad, Khorshid
dc.date2020-11
dc.date.accessioned2020-04-29T18:19:27Z
dc.date.available2020-04-29T18:19:27Z
dc.date.issued2020-04-26
dc.description.abstractObjective: To evaluate the relationship between placental pathology and the temporal profiles of “cytokine” (cytokines, chemokines and growth factors) levels in extremely preterm infants. Study design: A prospective cohort study of preterm infants born before 29 weeks gestational age (GA) and admitted to the neonatal intensive care unit (NICU) between June 2017 and July 2018 (n=55). Levels of 27 cytokines were measured in blood obtained from the umbilical cord at birth, 24-72 hours, and 21-28 days of life. Cytokine levels were determined using the Bio-Rad Multiplex Immunoassay System. Placental pathology per the 2016 Amsterdam consensus criteria and grouped as normal (N), inflammation (I), vasculopathy (V), or combined vasculopathy and inflammation (V+I). Results: Complete data was available from 42 patients. Cord blood median levels of cytokines differed between groups with the highest levels observed in group V+I as compared to groups N, I and V for the following: Eotaxin (p = 0.038), G-CSF (p = 0.023), IFN-γ (p = 0.002), IL-1ra (p < 0.001), IL-4 (p = 0.005), IL-8 (p = 0.010), MCP-1 (p = 0.011), and TNFα (p = 0.002). Post hoc analysis revealed sex differences in group I, with higher median levels of FGF-basic (p = 0.03), G-CSF (p = 0.048), IL1b (p = 0.038), IL-1ra (p = 0.005), IL-8 (p = 0.005), MIP-1α (p = 0.048) and TNFα (p = 0.048) in females. Conclusion: Specific types of placental pathology may be associated with differential cytokine profiles in extremely preterm infants. Sampling from cord blood may help assess the pathological status of the placenta and potentially infer outcome risks for the infant.en_US
dc.identifier.citationZein, H. (2020). Temporal profile of blood cytokine levels and placental pathology in extremely preterm infants (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/37734
dc.identifier.urihttp://hdl.handle.net/1880/111918
dc.language.isoengen_US
dc.publisher.facultyScienceen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subject.classificationEducation--Sciencesen_US
dc.subject.classificationNeuroscienceen_US
dc.subject.classificationBiophysics--Medicalen_US
dc.titleTemporal profile of blood cytokine levels and placental pathology in extremely preterm infantsen_US
dc.typemaster thesisen_US
thesis.degree.disciplineMedicine – Neuroscienceen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrueen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ucalgary_2020_zein_hussein.pdf
Size:
2.04 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Theses and Dissertations