Correlating Obstructive Symptoms with Stricture Severity in Ileal Crohn’s Disease
Date
2024-11-28
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Abstract
Crohn’s Disease (CD) can manifest as inflammatory (non-stricturing), fibrostenotic (stricturing) and fistulizing or penetrating phenotypes. Stricturing CD, the main focus of this thesis, involves luminal narrowing and, which is often progressive leading to obstruction of the affected bowel segment. Obstructive symptoms (OS) in CD strictures can be assessed using the Stricture Definition and Treatment (STRIDENT) trial-used OS scoring system and CREOLE OS score. Clinically, OS are typically linked to advanced strictures, strictures can often result in dietary restrictions and surgery. No studies have been published to date, evaluating the severity of CD strictures and OS. Understanding the correlation between symptoms and strictures is crucial as regulatory bodies assess drug efficacy based on symptom response in CD trials. Intestinal ultrasound (IUS) accurately evaluates strictures morphology, with stricture severity and length, using established criteria: bowel wall thickness > 3mm, luminal narrowing (<1cm), with any pre-stenotic dilation (PSD) size (cm). The aim of this thesis based stsudy aims to determine if the OS of pain, bloating, nausea and/ or vomiting when comparing among CD phenotypes, and if specific OS correlate with any of the definitive stricture parameters.
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Keywords
Crohns Disease, Medicine, Strictures, Bowel Obstruction, Surgery, Symptoms, Obstructive Symptoms
Citation
Saunders, B. (2025). Correlating obstructive symptoms with stricture severity in ileal Crohn’s disease (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.