Altered aortic 3D hemodynamics and geometry in pediatric Marfan syndrome patients

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dc.contributor.authorvan der Palen, Roel L F
dc.contributor.authorBarker, Alex J
dc.contributor.authorBollache, Emilie
dc.contributor.authorGarcia, Julio
dc.contributor.authorRose, Michael J
dc.contributor.authorvan Ooij, Pim
dc.contributor.authorYoung, Luciana T
dc.contributor.authorRoest, Arno A W
dc.contributor.authorMarkl, Michael
dc.contributor.authorRobinson, Joshua D
dc.contributor.authorRigsby, Cynthia K
dc.date.accessioned2018-11-07T17:03:43Z
dc.date.available2018-11-07T17:03:43Z
dc.date.issued2017-03-17
dc.date.updated2018-11-07T17:03:43Z
dc.description.abstractAbstract Background Blood flow dynamics make it possible to better understand the development of aortopathy and cardiovascular events in patients with Marfan syndrome (MFS). Aortic 3D blood flow characteristics were investigated in relation to aortic geometry in children and adolescents with MFS. Methods Twenty-five MFS patients (age 15.6 ± 4.0 years; 11 females) and 21 healthy controls (age 16.0 ± 2.6 years; 12 females) underwent magnetic resonance angiography and 4D flow CMR for assessment of thoracic aortic size and 3D blood flow velocities. Data analysis included calculation of aortic diameter and BSA-indexed aortic dimensions (Z-score) along the thoracic aorta, 3D mean systolic wall shear stress (WSSmean) in ten aortic segments and assessment of aortic blood flow patterns. Results Aortic root (root), ascending (AAo) and descending (DAo) aortic size was significantly larger in MFS patients than healthy controls (Root Z-score: 3.56 ± 1.45 vs 0.49 ± 0.78, p < 0.001; AAo Z-score 0.21 ± 0.95 vs −0.54 ± 0.64, p = 0.004; proximal DAo Z-score 2.02 ± 1.60 vs 0.56 ± 0.66, p < 0.001). A regional variation in prevalence and severity of flow patterns (vortex and helix flow patterns) was observed, with the aortic root and the proximal DAo (pDAo) being more frequently affected in MFS. MFS patients had significantly reduced WSSmean in the proximal AAo (pAAo) outer segment (0.65 ± 0.12 vs. 0.73 ± 0.14 Pa, p = 0.029) and pDAo inner segment (0.74 ± 0.17 vs. 0.87 ± 0.21 Pa, p = 0.021), as well as higher WSSmean in the inner segment of the distal AAo (0.94 ± 0.14 vs. 0.84 ± 0.15 Pa, p = 0.036) compared to healthy subjects. An inverse relationship existed between pDAo WSSmean and both pDAo diameter (R = −0.53, p < 0.001) and % diameter change along the pDAo segment (R = −0.64, p < 0.001). Conclusions MFS children and young adults have altered aortic flow patterns and differences in aortic WSS that were most pronounced in the pAAo and pDAo, segments where aortic dissection or rupture often originate. The presence of vortex flow patterns and abnormal WSS correlated with regional size of the pDAo and are potentially valuable additional markers of disease severity.
dc.identifier.citationJournal of Cardiovascular Magnetic Resonance. 2017 Mar 17;19(1):30
dc.identifier.doihttps://doi.org/10.1186/s12968-017-0345-7
dc.identifier.urihttp://hdl.handle.net/1880/109004
dc.identifier.urihttps://doi.org/10.11575/PRISM/44052
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.titleAltered aortic 3D hemodynamics and geometry in pediatric Marfan syndrome patients
dc.typeJournal Article
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