QuantitativeT2: interactive quantitative T2 MRI witnessed in mouse glioblastoma

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dc.contributor.authorAli, Tonima
dc.contributor.authorBjarnason, Thorarin
dc.contributor.authorSenger, Donna
dc.contributor.authorDunn, Jeff F.
dc.contributor.authorJoseph, Jeffery
dc.contributor.authorMitchell, Joseph
dc.date.accessioned2016-03-24T16:26:47Z
dc.date.available2016-03-24T16:26:47Z
dc.date.issued2015-07-21
dc.description.abstractThe aim of this study was to establish an advanced analytical platform for complex in vivo pathologies. We have developed a software program, QuantitativeT2, for voxel-based real-time quantitative T2 magnetic resonance imaging. We analyzed murine brain tumors to confirm feasibility of our method for neurological conditions. Anesthetized mice (with invasive gliomas, and controls) were imaged on a 9.4 Tesla scanner using a Carr–Purcell–Meiboom–Gill sequence. The multiecho T2 decays from axial brain slices were analyzed using QuantitativeT2. T2 distribution histograms demonstrated substantial characteristic differences between normal and pathological brain tissues. Voxel-based quantitative maps of tissue water fraction (WF) and geometric mean T2 (gmT2) revealed the heterogeneous alterations to water compartmentalization caused by pathology. The numeric distribution of WF and gmT2 indicated the extent of tumor infiltration. Relative evaluations between in vivo scans and ex vivo histology indicated that the T2s between 30 and 150 ms were related to cellular density and the integrity of the extracellular matrix. Overall, QuantitativeT2 has demonstrated significant advancements in qT2 analysis with real-time operation. It is interactive with an intuitive workflow; can analyze data from many MR manufacturers; and is released as open-source code to encourage examination, improvement, and expansion of this method.en_US
dc.description.grantingagencyAlberta Innovates Health Solutions; Alberta Innovates Technology Futures; Alberta Cancer Foundation; Southern Alberta Cancer Research Instituteen_US
dc.description.refereedYesen_US
dc.identifier.citationAli, T., T. Bjarnason, D. Senger, J. F. Dunn, J. Joseph and R. Mitchell. (2015). QuantitativeT2: interactive quantitative T2 MRI witnessed in mouse glioblastoma. J Medical Imaging. 2(3): 036002.en_US
dc.identifier.doi10.1117/1.JMI.2.3.036002
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33529
dc.identifier.issn2164-2788
dc.identifier.urihttp://hdl.handle.net/1880/51123
dc.language.isoenen_US
dc.publisherScientific Research Publishingen_US
dc.publisher.departmentBiomedical Engineering and Medical Physicsen_US
dc.publisher.facultyScience and Engineeringen_US
dc.publisher.institutionQueensland University of Technologyen_US
dc.publisher.urlhttp://www.scirp.org/en_US
dc.relation.ispartofseriesJournal of Medical Imaging;
dc.subjectmagnetic resonance imagingen_US
dc.subjectQuantitativeT2en_US
dc.subjectqT2en_US
dc.subjectsoftwareen_US
dc.subjectglioblastomaen_US
dc.titleQuantitativeT2: interactive quantitative T2 MRI witnessed in mouse glioblastomaen_US
dc.title.alternativeAdvanced multi-exponential analysis of mouse glioblastoma by interactive quantitative T2 MRIen_US
dc.typejournal article
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