The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels
| dc.contributor.author | Simms, Brent A. | |
| dc.contributor.author | Zamponi, Gerald W. | |
| dc.date.accessioned | 2018-05-29T15:04:35Z | |
| dc.date.available | 2018-05-29T15:04:35Z | |
| dc.date.issued | 2012-03-02 | |
| dc.description.abstract | A loss of function of the L-type calcium channel, Cav1.2, results in a cardiac specific disease known as Brugada syndrome. Although many Brugada syndrome channelopathies reduce channel function, one point mutation in the N-terminus of Cav1.2 (A39V) has been shown to elicit disease a phenotype because of a loss of surface trafficking of the channel. This lack of cell membrane expression could not be rescued by the trafficking chaperone CavĪ². | en_US |
| dc.description.sponsorship | Sponsored by the Open Access Authors Fund | en_US |
| dc.identifier.citation | Simms, B. A., & Zamponi, G. W. (2012). The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels. Molecular Brain, 5(1). https://doi.org/10.1186/1756-6606-5-9 | en_US |
| dc.identifier.doi | http://dx.doi.org/10.1186/1756-6606-5-9 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1880/106698 | |
| dc.identifier.uri | https://doi.org/10.11575/PRISM/43733 | |
| dc.language.iso | en | en_US |
| dc.publisher | BioMed Central Ltd. | en_US |
| dc.publisher.department | Physiology & Pharmacology | en_US |
| dc.publisher.faculty | Cumming School of Medicine | en_US |
| dc.publisher.institution | University of Calgary | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
| dc.title | The Brugada syndrome mutation A39V does not affect surface expression of neuronal rat Cav1.2 channels | en_US |
| dc.type | journal article | en_US |