A Meta-Analysis of Hydroxyurea Use for β-thalassemia: Implications for Clinical Practice and Medical Education

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atmire.migration.oldid3851
dc.contributor.advisorKassam, Aliya
dc.contributor.authorAlgiraigri, Ali
dc.contributor.committeememberOddone Paolucci, Elizabeth
dc.contributor.committeememberWright, Nicola
dc.date.accessioned2015-11-18T18:35:32Z
dc.date.embargolift2016-02-22T07:00:00Z
dc.date.issued2015-11-18
dc.date.submitted2015en
dc.description.abstractChronic blood transfusion remains the most feasible therapeutic option for the majority of patients with severe β-thalassemia. However, it is associated with serious risks and complications. An alternative option is desirable and may prevent some of the problems associated with current therapy. Hydroxyurea (HU), an oral chemotherapeutic drug, is expected to increase hemoglobin, thereby minimizing the burden of blood transfusion and its complications. The objective of this study was to conduct a systematic review and meta-analysis to evaluate the clinical efficacy and safety of HU in patients with severe β-thalassemia. HU appears to be effective, well tolerated and associated with mild and transient adverse events; however, large randomized clinical trials (RCTs) should be done to confirm such findings. Nonetheless, based on the results of the present meta-analysis, it is recommended that current practice guidelines for severe β-thalassemia be appended to include a trial of HU.en_US
dc.identifier.citationAlgiraigri, A. (2015). A Meta-Analysis of Hydroxyurea Use for β-thalassemia: Implications for Clinical Practice and Medical Education (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/24785en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/24785
dc.identifier.urihttp://hdl.handle.net/11023/2643
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEducation
dc.subjectEducation
dc.subjectMedicine and Surgery
dc.titleA Meta-Analysis of Hydroxyurea Use for β-thalassemia: Implications for Clinical Practice and Medical Education
dc.typemaster thesis
thesis.degree.disciplineCommunity Health Sciences
thesis.degree.disciplineMedical Education
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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