Pulmonary Hypertension: Insights From the Reservoir-Wave Approach

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atmire.migration.oldid4461
dc.contributor.advisorTyberg, John
dc.contributor.advisorFine, Nowell
dc.contributor.authorGhimire, Anukul
dc.contributor.committeememberBelenkie, Israel
dc.contributor.committeememberGrant, Andrew
dc.date.accessioned2016-05-19T16:32:55Z
dc.date.available2016-05-19T16:32:55Z
dc.date.issued2016
dc.date.submitted2016en
dc.description.abstractWe employed the reservoir-wave approach to analyze high-fidelity pulmonary arterial (PA) pressure and Doppler flow velocity in 11 patients with varying cardiac diseases. Our specific objectives were to (1) to characterize PA wave pattern and (2) evaluate right ventricular (RV) performance. Wave pressure was partitioned into its forward and backward components. Among patients with lower PA pressures, pressure-decreasing and flow-increasing reflected waves that assist RV ejection were detected. Among the more pulmonary hypertensive patients, pressure-increasing and flow-decreasing reflected waves that impede RV ejection were detected. The four patients with the highest PA pressures showed an early systolic deceleration in flow, which was found to coincide with reflected pressure-increasing, flow-decreasing waves. Wave work done by the RV increased with PA pressure, but expressed as a fraction of total RV work, did not change. The reservoir-wave approach may prove to be a valuable tool to characterize PA-RV interaction and evaluate RV performance.en_US
dc.identifier.citationGhimire, A. (2016). Pulmonary Hypertension: Insights From the Reservoir-Wave Approach (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/27482en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/27482
dc.identifier.urihttp://hdl.handle.net/11023/3027
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectEducation--Sciences
dc.subjectPhysiology
dc.subject.classificationHemodynamicsen_US
dc.subject.classificationCardiovascularen_US
dc.titlePulmonary Hypertension: Insights From the Reservoir-Wave Approach
dc.typemaster thesis
thesis.degree.disciplineCardiovascular & Respiratory Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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