Can Mesenchymal Stem Cells Inhibit the Formation of Saccular Aneurysms?

Simple item page
atmire.migration.oldid5774
dc.contributor.advisorSen, Arindom
dc.contributor.advisorMitha, Alim P.
dc.contributor.authorAvery, Michael B
dc.contributor.committeememberRinker, Kristina
dc.contributor.committeememberEesa, Muneer
dc.date.accessioned2017-07-14T16:03:02Z
dc.date.available2017-07-14T16:03:02Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractIntracranial saccular aneurysms are pathological dilations of cerebral blood vessels that can spontaneously rupture leading to significant morbidity and mortality. Our current understanding of saccular aneurysm pathogenesis involves a complex interplay of predisposing factors and inflammatory cascades, leading to an outpouching at the site of a vessel bifurcation. While several treatments exist today, none are aimed at preventing aneurysm formation. Mesenchymal stem cells are pluripotent cells that have interesting immunomodulatory properties and have been studied in the context of many inflammatory diseases. Few studies have addressed aneurysms and suggest that these cells have the potential to be adjuvants to current treatment modalities in treating fully formed aneurysms. This thesis details the first studies investigating the use of mesenchymal stem cells in preventing the formation of saccular aneurysms. A pre- clinical trial was conducted, as well as an in vivo localization experiment to determine the potential mechanism of action.en_US
dc.identifier.citationAvery, M. B. (2017). Can Mesenchymal Stem Cells Inhibit the Formation of Saccular Aneurysms? (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25202en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25202
dc.identifier.urihttp://hdl.handle.net/11023/3950
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectAnimal Physiology
dc.subjectBiology--Cell
dc.subjectNeuroscience
dc.subjectBiophysics--Medical
dc.subject.otherMesenchymal Stem Cell
dc.subject.otherMesenchymal Stromal Cell
dc.subject.otherAneurysm
dc.subject.otherCell Therapy
dc.subject.otherPathogenesis
dc.titleCan Mesenchymal Stem Cells Inhibit the Formation of Saccular Aneurysms?
dc.typemaster thesis
thesis.degree.disciplineNeuroscience
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
Files
Collections
Open Theses and Dissertations