Anatomy and Function of Synaptic Zinc in the Striatum

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atmire.migration.oldid3750
dc.contributor.advisorDyck, Richard
dc.contributor.authorThackray, Sarah Elizabeth
dc.date.accessioned2015-09-28T22:27:52Z
dc.date.available2015-11-20T08:00:42Z
dc.date.issued2015-09-28
dc.date.submitted2015en
dc.description.abstractSynaptic zinc is located in many regions of the brain. One area that contains a high amount is the input center of the basal ganglia: the striatum. Environmental enrichment was used to examine potential changes in morphology of striatal cells of mice with (ZnT3 wildtype) and without (ZnT3 knockout) the zinc transporter (ZnT3) necessary to load zinc into vesicles. No changes were found in dendritic length for any regions of the striatum. However, all regions of the striatum showed an increase in spine density in both genotypes, with enriched ZnT3 KO mice having a greater increase in the nucleus accumbens region. ZnT3 mice were also tested on a battery of motor behavioural tasks. ZnT3 KO mice may be hyperactive, as evidenced by their performance on the pole task, and impulsive, as evidenced by their inaccurate performance on a skilled reach task, when compared to ZnT3 WT mice.en_US
dc.identifier.citationThackray, S. E. (2015). Anatomy and Function of Synaptic Zinc in the Striatum (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/24841en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/24841
dc.identifier.urihttp://hdl.handle.net/11023/2537
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNeuroscience
dc.subject.classificationsynaptic zincen_US
dc.subject.classificationstriatumen_US
dc.subject.classificationZnT3en_US
dc.subject.classificationexperience-dependent plasticityen_US
dc.subject.classificationmotor behaviouren_US
dc.titleAnatomy and Function of Synaptic Zinc in the Striatum
dc.typemaster thesis
thesis.degree.disciplinePsychology
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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