Conceptus-derived Fibrinogen and its Implication in Equine Pregnancy

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atmire.migration.oldid5580
dc.contributor.advisorKlein, Claudia
dc.contributor.authorMacedo da Silva, Alysson
dc.contributor.committeememberWynne-Edwards, Katherine
dc.contributor.committeememberKastelic, John
dc.contributor.committeememberMacPhee, Daniel
dc.date.accessioned2017-05-02T14:38:21Z
dc.date.available2017-05-02T14:38:21Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractThe equine conceptus presents an extensive mobile stage from days 9 to 16 after ovulation, during which it becomes fixed to one of the uterine horns. Throughout mobility, the conceptus secretes fibrinogen (an integrin-binding ECM). We hypothesized that conceptus-derived fibrinogen is converted into fibrin and aids in fixation via integrin receptors. We determined that RGD-binding integrins are expressed in endometrial and embryonic/fetal cells and interact with fibrinogen. Moreover, endometrial and embryonic cells presented the machinery to convert fibrinogen into fibrin and maintain the fibrin network. Overall, we demonstrated that conceptus-derived fibrinogen is likely converted to fibrin at the embryo-maternal interface and mediates cell adhesion via RGD-binding integrins.en_US
dc.identifier.citationMacedo da Silva, A. (2017). Conceptus-derived Fibrinogen and its Implication in Equine Pregnancy (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25409en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25409
dc.identifier.urihttp://hdl.handle.net/11023/3804
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultyVeterinary Medicine
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectVeterinary Science
dc.subject.otherHorse
dc.subject.otherReproduction
dc.subject.otherEmbryo
dc.subject.otherEquine Pregnancy
dc.subject.otherConceptus Fixation
dc.titleConceptus-derived Fibrinogen and its Implication in Equine Pregnancy
dc.typemaster thesis
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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