Molecular characterization of economically important poultry viruses in western Canada

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dc.contributor.advisorAbdul-Careem, Mohamed Faizal
dc.contributor.authorPalomino-Tapia, Victor A.
dc.contributor.committeememberSellers, Holly S.
dc.contributor.committeemembervan der Meer, Frank
dc.contributor.committeememberMitevski, Darko
dc.date2021-02
dc.date.accessioned2020-12-08T21:31:44Z
dc.date.available2020-12-08T21:31:44Z
dc.date.issued2020-12-04
dc.description.abstractAvian Reovirus (ARV), Chicken Astrovirus (CAstV), and Hemorrhagic Enteritis Virus (HEV) are important enteric pathogens affecting poultry production around the world. These agents are the causative agents of Viral Arthritis (VA), White Chick Syndrome (WCS), and Hemorrhagic Enteritis (HE), respectively. In meat-type chickens, pathogenic strains of ARV can replicate in the joints leading to edema, inflammatory cell infiltrate, and fibrosis, which results in rupture of tendons. Similarly, pathogenic strains of CAstV can cause transient increase in mid to late embryo mortality, reducing hatchability between 4-68%, with some hatched birds exhibiting pale plumage; these “white chicks” (WCS) usually die within the first week of life. In turkeys, HEV infection has two presentations: 1) A clinical disease consisting on gastrointestinal hemorrhages, depression and immunosuppression (Clinical HE); and 2) subclinical infection, consisting in immunosuppression and causing economical losses due to secondary infections and plant condemnations. In recent years, these diseases have gained importance in western Canada as a result of the economic losses sustained from these infections in: a) feed conversion, b) high number of culls/first week mortality, c) secondary bacterial infections, c) processing plant condemnations; and d) costly disruptions to the Canadian Supply Management system. This thesis focuses on molecular characterization of ARV, CAstV, and HEV obtained either from clinical samples (ARV, CAstV), or from cases suspected to have subclinical infection (HEV) in poultry farms located in western Canada. The biological samples from chickens (ARV, CAStV) and turkeys (HEV) were collected from cases submitted for post-mortem examination and diagnosis to Poultry Health Services (PHS), a private poultry consulting firm, located in Airdrie, Alberta, western Canada. Further studies are required to assess the virulence of these isolates for understanding their impact in the western Canada Poultry Industry and for the implementation or enhancement of vaccination practices.en_US
dc.identifier.citationPalomino-Tapia, V. A. (2020). Molecular characterization of economically important poultry viruses in western Canada (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/38422
dc.identifier.urihttp://hdl.handle.net/1880/112814
dc.language.isoengen_US
dc.publisher.facultyVeterinary Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectMolecular characterizationen_US
dc.subjectAvian Reovirusen_US
dc.subjectViral Arthritisen_US
dc.subjectChicken Astrovirusen_US
dc.subjectWhite Chick Syndromeen_US
dc.subjectTurkey Hemorrhagic Enteritis Virusen_US
dc.subjectHemorrhagic Enteritisen_US
dc.subjectmutationen_US
dc.subjectrecombinationen_US
dc.subjectpoultry enteric virusesen_US
dc.subject.classificationBiology--Molecularen_US
dc.subject.classificationVirologyen_US
dc.titleMolecular characterization of economically important poultry viruses in western Canadaen_US
dc.typedoctoral thesisen_US
thesis.degree.disciplineVeterinary Medical Sciencesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameDoctor of Philosophy (PhD)en_US
ucalgary.item.requestcopytrueen_US
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