Severe Undifferentiated Vasoplegic Shock Refractory to Vasoactive Agents Treated with Methylene Blue

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dc.contributor.authorManji, Farheen
dc.contributor.authorWierstra, Benjamin
dc.contributor.authorPosadas, Juan
dc.date.accessioned2018-09-27T11:18:37Z
dc.date.available2018-09-27T11:18:37Z
dc.date.issued2017-10-02
dc.date.updated2018-09-27T11:18:37Z
dc.description.abstractMethylene blue is a phenothiazine-related heterocyclic aromatic molecule presently used in the treatment of methemoglobinemia. Recently, it has been implicated in the treatment of severe refractory vasoplegic shock caused by anaphylaxis, sepsis, or postcardiopulmonary bypass. We present a case of a 27-year-old male with profound vasoplegic shock of unknown etiology which was refractory to vasopressors who responded within hours to a single dose of methylene blue. Additionally, we review the evidence of methylene blue’s role in the treatment of shock. This case illustrates a diagnostic approach and treatment options in the setting of undifferentiated vasodilatory shock and outlines a new and emerging role for methylene blue in this clinical setting.
dc.description.versionPeer Reviewed
dc.identifier.citationFarheen Manji, Benjamin Wierstra, and Juan Posadas, “Severe Undifferentiated Vasoplegic Shock Refractory to Vasoactive Agents Treated with Methylene Blue,” Case Reports in Critical Care, vol. 2017, Article ID 8747326, 4 pages, 2017. doi:10.1155/2017/8747326
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33032
dc.identifier.urihttp://dx.doi.org/10.1155/2017/8747326
dc.identifier.urihttp://hdl.handle.net/1880/108096
dc.language.rfc3066en
dc.rights.holderCopyright © 2017 Farheen Manji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleSevere Undifferentiated Vasoplegic Shock Refractory to Vasoactive Agents Treated with Methylene Blue
dc.typeJournal Article
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