Effect of Mammography Screening on Incidence and Mortality of Breast Cancer in Alberta
| dc.contributor.advisor | Dickinson, James A. | |
| dc.contributor.author | Efegoma, Yvonne Chuka | |
| dc.contributor.committeemember | Kopciuk, Karen Arlene | |
| dc.contributor.committeemember | Shack, Lorraine G. | |
| dc.date | 2020-11 | |
| dc.date.accessioned | 2020-07-14T16:51:16Z | |
| dc.date.available | 2020-07-14T16:51:16Z | |
| dc.date.issued | 2020-07-13 | |
| dc.description.abstract | Background: Breast cancer is the second leading cause of cancer death among Canadian women, and to decrease this burden mammography screening is widespread. If effective, mammography screening should reduce the incidence of late-stage cancer by early detection, allow time for prompt treatment and result in lower mortality. Given Alberta’s universal health system, with organised screening reaching around 63% of the target population annually, we set out to determine how much screening mammography has decreased presentation of late-stage cancer, and potentially reduced mortality from breast cancer, among Alberta women. Methods: We conducted a historical birth-cohort study and trend analysis using data from the Alberta Cancer registry from 1982 to 2017. We compared stage specific incidence and mortality over the years and by birth cohorts, taking into consideration the introduction and evolution of screening mammography to measure how much effect screening has on observed trends. We used Joinpoint regression analysis to test statistically significance of observed trends. Results: From 2006 to 2017, incidence of early-stage breast cancers among women aged 50 to 79 years increased by 33 per 100,000 women at an average rate of 1.2% annually (p<0.001), while incidence of late-stage cancer decreased by 3 per 100,000 women at a rate of 0.8 annually (p=0.3). From 2001 to 2018, deaths from breast cancer reduced by 29 per 100,000 women at 2.3% annually (p<0.001), while all-cause mortality reduced by 9 per 100,000 at 0.5% annually (p=0.1) in women previously diagnosed with breast cancer. Each subsequent recent birth cohort had higher rates of early breast cancer at specific ages while the incidence of late-stage cancers reduced with recent cohorts at specific ages. Conclusion: There has been some reduction in the incidence of late-stage breast cancer and breast cancer deaths between 2006 and 2018. This has been associated with an excess increase in early-stage cancers, which may be explained by overdiagnosis. These may be related to changes in screening mammography in that period. Women need to be educated on the effectiveness of screening mammography in order to make informed decisions about their screening practices | en_US |
| dc.identifier.citation | Efegoma, Y. C. (2020). Effect of Mammography Screening on Incidence and Mortality of Breast Cancer in Alberta (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. | en_US |
| dc.identifier.doi | http://dx.doi.org/10.11575/PRISM/38018 | |
| dc.identifier.uri | http://hdl.handle.net/1880/112299 | |
| dc.language.iso | eng | en_US |
| dc.publisher.faculty | Cumming School of Medicine | en_US |
| dc.publisher.institution | University of Calgary | en |
| dc.rights | University of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission. | en_US |
| dc.subject.classification | Education--Health | en_US |
| dc.subject.classification | Epidemiology | en_US |
| dc.subject.classification | Oncology | en_US |
| dc.subject.classification | Public Health | en_US |
| dc.title | Effect of Mammography Screening on Incidence and Mortality of Breast Cancer in Alberta | en_US |
| dc.type | master thesis | en_US |
| thesis.degree.discipline | Medicine – Community Health Sciences | en_US |
| thesis.degree.grantor | University of Calgary | en_US |
| thesis.degree.name | Master of Science (MSc) | en_US |
| ucalgary.item.requestcopy | true | en_US |