The Effect of Transcranial Direct Current Stimulation on GABA and Glx in Children During Motor Learning

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dc.contributor.advisorHarris, Ashley D.
dc.contributor.authorNwaroh, Chidera
dc.contributor.committeememberKirton, Adam
dc.contributor.committeememberBray, Signe L.
dc.contributor.committeememberCondliffe, Elizabeth G.
dc.contributor.committeememberDunn, Jeffrey F.
dc.date2019-11
dc.date.accessioned2019-06-11T13:36:28Z
dc.date.available2019-06-11T13:36:28Z
dc.date.issued2019-06-07
dc.description.abstractTranscranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that safely modulates brain activity. Several studies have shown that anodal tDCS of the primary motor cortex (M1) facilitates motor learning and plasticity but there is little information about the underlying mechanisms. Additionally, studies have shown that tDCS can affect local levels of GABA and glutamate both of which are associated with skill acquisition and plasticity. This study aimed to quantify changes in GABA and Glx in response to 5 consecutive days of anodal tDCS or high definition tDCS targeting the M1 in children. Our results suggest HD-tDCS elicits a neurochemical response that is different from anodal tDCS despite resulting in similar motor enhancements. Additionally, we identified a relationship between left sensorimotor cortex GABA and improvements in motor performance. Overall, our results suggest that the developing brain responds differently to tDCS when compared to adult literature.en_US
dc.identifier.citationNwaroh, C. (2019). The Effect of Transcranial Direct Current Stimulation on GABA and Glx in Children During Motor Learning (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/36629
dc.identifier.urihttp://hdl.handle.net/1880/110488
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectmagnetic resonance spectroscopy (MRS)en_US
dc.subjectGABAen_US
dc.subjectGlutmateen_US
dc.subjecttranscranial direct current stimulation (tDCS)en_US
dc.subjectGABA-edited MRSen_US
dc.subject.classificationNeuroscienceen_US
dc.titleThe Effect of Transcranial Direct Current Stimulation on GABA and Glx in Children During Motor Learningen_US
dc.typemaster thesisen_US
thesis.degree.disciplineMedicine – Medical Sciencesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameMaster of Science (MSc)en_US
ucalgary.item.requestcopytrue
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