Detection of inter-hemispheric functional connectivity in motor cortex with coherence analysis

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dc.contributor.authorVarshney, V.P.
dc.contributor.authorLiapounova, N.
dc.contributor.authorGolestani, A. M.
dc.contributor.authorGoodyear, B.
dc.contributor.authorDunn, Jeffery F.
dc.date.accessioned2017-03-16T21:55:44Z
dc.date.available2017-03-16T21:55:44Z
dc.date.issued2012
dc.description.abstractFunctional near-infrared spectroscopy (fNIRS) is showing promise as an alternate method to fMRI for studying cortical function. Resting state studies in both methods are showing functional linkages. The strength of functional connections is typically quantified by the level of significance of the temporal synchrony between brain regions, termed resting-state functional connectivity. Coherence analysis of resting state allows for phase insensitive and frequency specific analysis. This paper provides a detailed method for undertaking fNIRS in combination with resting-state coherence analysis. We show that maps of inter-hemispheric resting-state functional connectivity between the motor cortices can be reliably generated, and the frequency responses (to 50 Hz) for both oxy- and deoxyhemoglobin. Frequencies of 0-0.1 Hz provide robust data as have been shown previously. Higher frequencies (up to 5 Hz) also exhibit high coherence. Deoxyhemoglobin also shows high coherence above 10Hz. Coherence is similar during both resting and task activated states. fNIRS allows for mapping cortical function and, in combination with coherence analysis, allows one to study variations in frequency response.en_US
dc.description.grantingagencyNIH RO1, Canadian Institutes of Health Research, National Sciences and Engineering Research Council Canada, Alberta Heritage Foundation for Medical Research Summer Studentshipen_US
dc.description.refereedYesen_US
dc.identifier.citationVARSHNEY, V. et al. Detection of inter-hemispheric functional connectivity in motor cortex with coherence analysis. Journal of the European Optical Society - Rapid publications, Europe, v. 7, nov. 2012.en_US
dc.identifier.doi10.2971/jeos.2012.12047
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33481
dc.identifier.grantnumberEB002085, FIN 79260en_US
dc.identifier.issn1990-2573
dc.identifier.urihttp://hdl.handle.net/1880/51864
dc.language.isoenen_US
dc.publisherEuropean Optical Societyen_US
dc.publisher.corporateUniversity of Calgary
dc.publisher.departmentRadiologyen_US
dc.publisher.facultyMedicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectcoherenceen_US
dc.subjectnear infrared tomograhyen_US
dc.subjectfunctional connectivityen_US
dc.subjectopticsen_US
dc.subjectbrainen_US
dc.subjectcoherence analysisen_US
dc.titleDetection of inter-hemispheric functional connectivity in motor cortex with coherence analysisen_US
dc.typejournal article
thesis.degree.disciplineRadiology / Physiology / Clinical Neurosciences
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