Anti-inflammatory Properties of Retinoids and Retinoid Derivatives in Innate Immune Cells
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2013-09-06
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Abstract
Clearance of apoptotic neutrophils following infection is critical for the resolution of inflammation. Despite demonstrating immunomodulatory properties, the effects of retinoids in neutrophils in the context of an inflammatory response remain unknown. The objective of this project was to evaluate the immunomodulatory properties of retinoic acid (RA) and oxidatively transformed carotene-β (OxC-β) in a model of Mannheimia haemolytica-induced bovine respiratory disease, which is characterized by severe inflammation. Results in vitro and in vivo demonstrate that both RA and OxC-β induce apoptosis in bovine neutrophils and that this phenomenon promotes efferocytosis in bovine macrophages. These effects occur in the absence of antimicrobial properties and any alteration in neutrophil function. The induction of neutrophil apoptosis and their subsequent phagocytic clearance by macrophages are key mechanisms that promote the resolution of inflammation following infection. As such, RA and OxC-β may represent novel nutraceuticals that confer anti-inflammatory benefits following infection.
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Duquette, S. (2013). Anti-inflammatory Properties of Retinoids and Retinoid Derivatives in Innate Immune Cells (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/24936