Psoriatic Arthritis Screening: A Systematic Review, Meta-Analysis, and Economic Evaluation

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dc.contributor.advisorSpackman, Eldon
dc.contributor.authorIragorri Amaya, Nicolas
dc.contributor.committeememberManns, Braden
dc.contributor.committeememberHazlewood, Glen S.
dc.date2018-11
dc.date.accessioned2018-10-01T18:32:52Z
dc.date.available2018-10-01T18:32:52Z
dc.date.issued2018-09-13
dc.description.abstractPsoriatic arthritis (PsA) is an autoimmune disease that affects the skin and the musculoskeletal system. It causes joint damage and psoriasis of the skin. Untreated disease is usually related to a delayed diagnosis and has been associated with physical disability and high treatment costs later on. Although expensive biologic therapy has proven to slow disease progression and improve health outcomes, rheumatologists have suggested initiating treatment with less expensive Disease Modifying Anti-Rheumatic Drugs (DMARDs). Identifying early PsA is expected to improve health outcomes through early treatment with DMARDs. It is also expected to reduce the proportion of severe disease and biologic treatment. Given that the prevalence of PsA among psoriasis patients is relatively high, dermatologists are well-positioned to screen for arthritis symptoms with already validated self-administered screening questionnaires for patients with psoriasis. The goal of this thesis is to systematically review the characteristics and accuracy estimates of the validated PsA screening tools (chapter 2). It also seeks to evaluate the cost-effectiveness of implementing a PsA screening program in Canada relative to the current practice where psoriasis patients are not systematically screened (chapter 3). The National Institute of Health Research is currently developing a randomized controlled trial for PsA screening in the United Kingdom that will inform the cost-effectiveness model presented in this thesis.en_US
dc.identifier.citationIragorri Amaya, N. (2018). Psoriatric Arthritis Screening: A Systematic Review, Meta-Analysis, and Economic Evaluation (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/33064en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/33064
dc.identifier.urihttp://hdl.handle.net/1880/108711
dc.language.isoeng
dc.publisher.facultyCumming School of Medicine
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectpsoriatic arthritis
dc.subjectscreening
dc.subjectEconomic Evaluation
dc.subjectdiagnostic meta-analysis
dc.subjectSystematic review
dc.subject.classificationEducation--Healthen_US
dc.subject.classificationEconomicsen_US
dc.titlePsoriatic Arthritis Screening: A Systematic Review, Meta-Analysis, and Economic Evaluation
dc.typemaster thesis
thesis.degree.disciplineCommunity Health Sciences
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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