Application of Microarray-Based Comparative Genomic Hybridization in Prenatal and Postnatal Settings: Three Case Reports

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dc.contributor.authorLiu, Jing
dc.contributor.authorBernier, Francois
dc.contributor.authorLauzon, Julie
dc.contributor.authorLowry, R. Brian
dc.contributor.authorChernos, Judy
dc.date.accessioned2018-09-27T12:00:41Z
dc.date.available2018-09-27T12:00:41Z
dc.date.issued2011-08-07
dc.date.updated2018-09-27T12:00:41Z
dc.description.abstractMicroarray-based comparative genomic hybridization (array CGH) is a newly emerged molecular cytogenetic technique for rapid evaluation of the entire genome with sub-megabase resolution. It allows for the comprehensive investigation of thousands and millions of genomic loci at once and therefore enables the efficient detection of DNA copy number variations (a.k.a, cryptic genomic imbalances). The development and the clinical application of array CGH have revolutionized the diagnostic process in patients and has provided a clue to many unidentified or unexplained diseases which are suspected to have a genetic cause. In this paper, we present three clinical cases in both prenatal and postnatal settings. Among all, array CGH played a major discovery role to reveal the cryptic and/or complex nature of chromosome arrangements. By identifying the genetic causes responsible for the clinical observation in patients, array CGH has provided accurate diagnosis and appropriate clinical management in a timely and efficient manner.
dc.description.versionPeer Reviewed
dc.identifier.citationJing Liu, Francois Bernier, Julie Lauzon, R. Brian Lowry, and Judy Chernos, “Application of Microarray-Based Comparative Genomic Hybridization in Prenatal and Postnatal Settings: Three Case Reports,” Genetics Research International, vol. 2011, Article ID 976398, 9 pages, 2011. doi:10.4061/2011/976398
dc.identifier.doihttps://doi.org/10.4061/2011/976398
dc.identifier.urihttp://hdl.handle.net/1880/108431
dc.identifier.urihttps://doi.org/10.11575/PRISM/44701
dc.language.rfc3066en
dc.rights.holderCopyright © 2011 Jing Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleApplication of Microarray-Based Comparative Genomic Hybridization in Prenatal and Postnatal Settings: Three Case Reports
dc.typeJournal Article
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