Effect of combined oligofructose and sitagliptin treatment on pre-pregnancy weight loss and gut microbiota in diet-induced obese rats

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dc.contributor.advisorReimer, Raylene
dc.contributor.authorEslinger, Amanda
dc.date.accessioned2012-07-13T00:12:13Z
dc.date.available2015-07-03T07:00:37Z
dc.date.issued2012-07-12
dc.date.submitted2012en
dc.description.abstractThe purpose of this study was to evaluate a combined dietary (oligofructose) and pharmacological (sitagliptin) anti-obesity therapy in diet-induced obese female Sprague-Dawley rats and determine if the effects persist throughout pregnancy and lactation. Body weight, glucose tolerance, satiety hormones, and gut microbiota were measured following obesity induction, treatment, and lactation phases of the study. During the treatment period, rats were randomized to seven experimental groups (n=13): (1) High Fat/High Sucrose (Obese Control); (2) Lean Control (Never Obese); (3) AIN-93M (Control-Treated Obese); (4) Oligofructose (Fiber-Treated Obese); (5) Sitagliptin (Drug-Treated Obese); (6) Oligofructose and Sitagliptin (Combination-Treated Obese); and (7) Caloric Restriction (Weight-Matched to Group 6). The combination of oligofructose and sitagliptin resulted in enhanced weight loss, improved glucose tolerance, and gut hormone and microbiota profiles associated with a lean phenotype. Some, but not all, benefits persisted to the end of lactation. The combined therapy may represent a novel anti-obesity treatment.en_US
dc.identifier.citationEslinger, A. (2012). Effect of combined oligofructose and sitagliptin treatment on pre-pregnancy weight loss and gut microbiota in diet-induced obese rats (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/25795en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/25795
dc.identifier.urihttp://hdl.handle.net/11023/111
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectNutrition
dc.subject.classificationOligofructoseen_US
dc.subject.classificationSitagliptinen_US
dc.subject.classificationObesityen_US
dc.subject.classificationmicrobiotaen_US
dc.subject.classificationSatietyen_US
dc.titleEffect of combined oligofructose and sitagliptin treatment on pre-pregnancy weight loss and gut microbiota in diet-induced obese rats
dc.typemaster thesis
thesis.degree.disciplineBiochemistry and Molecular Biology
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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