Cav3.2 T-type calcium channels control acute itch in mice

Gadotti, Vinicius M; Kreitinger, Joanna M; Wageling, Nicholas B; Budke, Dylan; Diaz, Philippe; Zamponi, Gerald W

Cav3.2 T-type calcium channels control acute itch in mice

dc.contributor.author	Gadotti, Vinicius M
dc.contributor.author	Kreitinger, Joanna M
dc.contributor.author	Wageling, Nicholas B
dc.contributor.author	Budke, Dylan
dc.contributor.author	Diaz, Philippe
dc.contributor.author	Zamponi, Gerald W
dc.date.accessioned	2020-09-06T00:09:25Z
dc.date.available	2020-09-06T00:09:25Z
dc.date.issued	2020-09-01
dc.date.updated	2020-09-06T00:09:25Z
dc.description.abstract	Abstract Cav3.2 T-type calcium channels are important mediators of nociceptive signaling, but their roles in the transmission of itch remains poorly understood. Here we report a key involvement of these channels as key modulators of itch/pruritus-related behavior. We compared scratching behavior responses between wild type and Cav3.2 null mice in models of histamine- or chloroquine-induced itch. We also evaluated the effect of the T-type calcium channel blocker DX332 in male and female wild-type mice injected with either histamine or chloroquine. Cav3.2 null mice exhibited decreased scratching responses during both histamine- and chloroquine-induced acute itch. DX332 co-injected with the pruritogens inhibited scratching responses of male and female mice treated with either histamine or chloroquine. Altogether, our data provide strong evidence that Cav3.2 T-type channels exert an important role in modulating histamine-dependent and -independent itch transmission in the primary sensory afferent pathway, and highlight these channels as potential pharmacological targets to treat pruritus.
dc.identifier.citation	Molecular Brain. 2020 Sep 01;13(1):119
dc.identifier.doi	https://doi.org/10.1186/s13041-020-00663-9
dc.identifier.uri	http://hdl.handle.net/1880/112498
dc.identifier.uri	https://doi.org/10.11575/PRISM/44831
dc.language.rfc3066	en
dc.rights.holder	The Author(s)
dc.title	Cav3.2 T-type calcium channels control acute itch in mice
dc.type	Journal Article