Nuclear localization of dirhodium(II) complexes in breast cancer cells by X-ray fluorescence microscopy

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dc.contributor.authorEnriquez Garcia, Alejandra
dc.contributor.authorLai, Barry
dc.contributor.authorGopinathan, Sesha Gopal
dc.contributor.authorHarris, Hugh H.
dc.contributor.authorShemanko, Carrie S.
dc.contributor.authorJalilehvand, Farideh
dc.date.accessioned2021-07-30T17:18:34Z
dc.date.embargolift2020-06-05
dc.date.issued2019-06-05
dc.description.abstractThe cellular distribution of three dirhodium(II) complexes with a paddlewheel structure was investigated using synchrotron-based X-ray fluorescence microscopy and cell viability studies. Complexes with vacant axial sites displayed cytotoxic activity and nuclear accumulation whereas complexes in which the axial positions were blocked showed little to no toxicity nor uptake.
dc.description.grantingagencyNatural Science and Engineering Research Council of Canada
dc.description.grantingagencyCanadian Foundation for Innovation
dc.description.grantingagencyCanadian Cancer Society
dc.description.grantingagencyDepartment of Innovation and Science of Province of Alberta
dc.identifier.citationEnriquez Garcia, A., Lai, B., Gopinathan, S. G., Harris, H. H., Shemanko, C. S., & Jalilehvand, F. (2019). Nuclear localization of dirhodium(II) complexes in breast cancer cells by X-ray fluorescence microscopy. Chemical Communications, 55(57), 8223–8226. doi:10.1039/c9cc00521h
dc.identifier.doi10.1039/C9CC00521H
dc.identifier.grantnumberRGPIN 2016-04546
dc.identifier.grantnumberRGPIN-2018-04773
dc.identifier.grantnumber#300072
dc.identifier.issn1359-7345
dc.identifier.urihttp://hdl.handle.net/1880/113674
dc.identifier.urihttps://dx.doi.org/10.11575/PRISM/39045
dc.language.isoenen
dc.language.isoeng
dc.publisherThe Royal Society of Chemistry
dc.publisher.departmentChemistry
dc.publisher.facultyScienceen
dc.publisher.hasversionPost-print
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.policyhttps://www.rsc.org/journals-books-databases/open-access/green-open-access/
dc.rightsUnless otherwise indicated, this material is protected by copyright and has been made available with authorization from the copyright owner. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en
dc.titleNuclear localization of dirhodium(II) complexes in breast cancer cells by X-ray fluorescence microscopy
dc.typejournal article
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