Analysis of GPCR/ion channel interactions

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dc.contributor.authorAltier, Christophe
dc.contributor.authorZamponi, Gerald W.
dc.date.accessioned2018-06-08T13:58:05Z
dc.date.available2018-06-08T13:58:05Z
dc.date.issued2011-01-01
dc.description.abstractVoltage-gated calcium channels are key regulators of calcium homeostasis in excitable cells. A number of cellular signaling pathways serve to fine tune calcium channel activity, including the activation of G protein-coupled receptors. Besides regulating channel activity via second messengers, GPCRs can also physically associate with calcium channels to directly regulate their functions, as well as their trafficking to and from the plasma membrane. Here we provide some methods that can be used to examine channel-receptor interactions and co-trafficking. While we focus on voltage-gated calcium channels, the techniques described herein are broadly applicable to other types of channels.en_US
dc.identifier.citationAltier, C., Zamponi, G. W. (2011). Analysis of GPCR/Ion channel interactions In Luttrell, L. M., Ferguson, S. G. (Eds.) Signal transduction protocols (pp. 215-225). New York: Humana Press.en_US
dc.identifier.doihttp://dx.doi.org/10.1007/978-1-61779-160-4_11en_US
dc.identifier.isbn9781617791598
dc.identifier.urihttp://hdl.handle.net/1880/106739
dc.identifier.urihttps://doi.org/10.11575/PRISM/43775
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleAnalysis of GPCR/ion channel interactionsen_US
dc.typebook parten_US
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