Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders

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dc.contributor.authorStys, Peter K.
dc.contributor.authorYou, Haitao
dc.contributor.authorZamponi, Gerald W.
dc.date.accessioned2018-06-06T15:37:40Z
dc.date.available2018-06-06T15:37:40Z
dc.date.issued2012-02-06
dc.description.abstractN-Methyl-D-aspartate (NMDA) receptors mediate a wide range of important nervous system functions. Conversely, excessive NMDA receptor activity leads to cytotoxic calcium overload and neuronal damage in a wide variety of CNS disorders. It is well established that NMDA receptors are tightly regulated by a number of cell signalling pathways. Recently, it has been shown that NMDA receptor activity is modulated by cellular prion protein (PrP(C)) in a copper-dependent manner. Here we give an overview of the current state of knowledge concerning the novel concept of potent modulation of this receptor's kinetics by copper ions, and the interplay between NMDA receptors and PrP(C) in the context of neurological diseases such as Alzheimer's disease, epilepsy, pain and depression.en_US
dc.identifier.citationStys, P. K., You, H., & Zamponi, G. W. (2012). Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders. The Journal of Physiology, 590(6), 1357–1368. https://doi.org/10.1113/jphysiol.2011.225276en_US
dc.identifier.doihttp://dx.doi.org/10.1113/jphysiol.2011.225276en_US
dc.identifier.urihttp://hdl.handle.net/1880/106724
dc.identifier.urihttps://doi.org/10.11575/PRISM/43778
dc.language.isoenen_US
dc.publisherThe Physiological Societyen_US
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.publisher.policyhttp://www.sherpa.ac.uk/romeo/search.php?issn=0022-3751en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleCopper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disordersen_US
dc.typejournal articleen_US
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