Mercury-induced toxicity of rat cortical neurons is mediated through N-Methyl-D-Aspartate receptors

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dc.contributor.authorXu, Fenglian
dc.contributor.authorFarkas, Svetlana
dc.contributor.authorKortbeek, Simone
dc.contributor.authorChen, Lina
dc.contributor.authorZhang, Fangxiong
dc.contributor.authorZamponi, Gerald W.
dc.contributor.authorSyed, Naweed I.
dc.date.accessioned2018-05-29T15:38:15Z
dc.date.available2018-05-29T15:38:15Z
dc.date.issued2012-09-14
dc.description.abstractMercury is a well-known neurotoxin implicated in a wide range of neurological or psychiatric disorders including autism spectrum disorders, Alzheimer's disease, Parkinson's disease, epilepsy, depression, mood disorders and tremor. Mercury-induced neuronal degeneration is thought to invoke glutamate-mediated excitotoxicity, however, the underlying mechanisms remain poorly understood. Here, we examine the effects of various mercury concentrations (including pathological levels present in human plasma or cerebrospinal fluid) on cultured, rat cortical neurons.en_US
dc.identifier.doihttp://dx.doi.org/10.1186/1756-6606-5-30en_US
dc.identifier.urihttp://hdl.handle.net/1880/106700
dc.identifier.urihttps://doi.org/10.11575/PRISM/43788
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.publisher.departmentCell Biology & Anatomyen_US
dc.publisher.departmentPhysiology & Pharmacologyen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.titleMercury-induced toxicity of rat cortical neurons is mediated through N-Methyl-D-Aspartate receptorsen_US
dc.typejournal articleen_US
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