Knee joint biomechanics in ovine models of post-traumatic osteoarthritis

Simple item page
dc.contributor.advisorShrive, Nigel
dc.contributor.authorShekarforoush, Seyed Mohammad Mehdi
dc.contributor.committeememberHart, David A.
dc.contributor.committeememberGoldsmith, Peter B.
dc.date2018-11
dc.date.accessioned2018-08-30T14:47:48Z
dc.date.available2018-08-30T14:47:48Z
dc.date.issued2018-08-23
dc.description.abstractPost-traumatic osteoarthritis (PTOA) is a sub-type of osteoarthritis, which can develop after injury to a joint and to date, many aspects of the etiology of the disease remain unclear. The main objective of this research was to quantify the subtle changes in the kinematic and the kinetic variables in the ovine stifle (knee) joint following different types of ligamentous and meniscal injury, and to investigate possible consequences of those biomechanical changes on gross morphological osteoarthritis-like damage in the joints. Overall, there was a high degree of inter-subject variability in the measured variables. We found different degrees of instabilities in the 6 degree-of-freedom kinematics and finite helical axis variables of the joints after ligamentous and meniscal injuries. Nevertheless, we did not detect correlations between the magnitudes of the changes in the kinematic variables with significant change and osteoarthritis-like damage in the joints. The kinematic analyses also suggest that the absolute change of the tibiofemoral translation vector could be an important risk factor for osteoarthritis development after ligament injuries. The magnitude of the joint angular velocities was decreased in extension during swing after different types of injury and the reduction was correlated with the morphological damage for two multiple ligament injury groups. We also found a weak correlation between the increase in some components of the tibiofemoral sliding velocity during stance after partial- anterior cruciate ligament (ACL) and medial collateral ligament (MCL) transection (p-ACL/MCL Tx) and the joint morphological damage in both the lateral and medial compartments of the joint. Kinetic analyses demonstrated a reduction in LCL load, slight increase in the PCL load and a consistent increase in the healed MCL load, especially during the stance stage of gait, after p-ACL/MCL Tx. Overall, the medial meniscus carried a higher magnitude of load than the lateral meniscus and the magnitude of the medial meniscus load was increased consistently in the animals through some parts of the gait cycle, 20 weeks after p-ACL/MCL Tx. No correlation was detected between variation in the meniscal loads and morphological damage in the joints, suggesting that the increase in the meniscal load after p-ACL/MCL Tx might not result in visible post-traumatic osteoarthritis damage in the short term after injury in an ovine model. Finally, we did not detect any consistent correlation between the changes in the ligament or meniscal loads and changes in analyzed kinematic variables, suggesting that ligamentous and meniscal loading regimes are not linear functions of different kinematic variables. The results improve our insight on how joint mechanical abnormalities can result in the development of post-traumatic osteoarthritis.en_US
dc.identifier.citationShekarforoush, S. M. M. (2018). Knee joint biomechanics in ovine models of post-traumatic osteoarthritis (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/32858en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/32858
dc.identifier.urihttp://hdl.handle.net/1880/107679
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.facultySchulich School of Engineering
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectPost traumatic osteoarthritis
dc.subjectKnee Injury
dc.subjectACL injury
dc.subjectKnee
dc.subjectLigament loads
dc.subjectknee kinematics
dc.subjectJoint angular velocity
dc.subjectJoint linear velocity
dc.subject.classificationApplied Mechanicsen_US
dc.subject.classificationEngineering--Biomedicalen_US
dc.subject.classificationEngineering--Mechanicalen_US
dc.titleKnee joint biomechanics in ovine models of post-traumatic osteoarthritis
dc.typedoctoral thesis
thesis.degree.disciplineBiomedical Engineering
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameDoctor of Philosophy (PhD)
ucalgary.item.requestcopytrue
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ucalgary_2018_shekarforoush_seyed.pdf
Size:
7.87 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.74 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Theses and Dissertations