Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits
Date
2010-08-25
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Society for Neuroscience
Abstract
NMDA receptors are typically excited by a combination of glutamate and glycine. Here we describe excitatory responses in CNS myelin that are gated by a glycine agonist alone and mediated by NR1/NR3 "NMDA" receptor subunits. Response properties include activation by d-serine, inhibition by the glycine-site antagonist CNQX, and insensitivity to the glutamate-site antagonist d-APV. d-Serine responses were abrogated in NR3A-deficient mice. Our results suggest the presence of functional NR1/NR3 receptors in CNS myelin.
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Citation
Pina-Crespo, J. C., Talantova, M., Micu, I., States, B., Chen, H. S., Tu, S., . . . Lipton, S. A. (2010). Excitatory Glycine Responses of CNS Myelin Mediated by NR1/NR3 "NMDA" Receptor Subunits. Journal of Neuroscience, 30(34), 11501-11505. doi:10.1523/jneurosci.1593-10.2010