Genome sequence of the sulfur-oxidizing Bathymodiolus thermophilus gill endosymbiont

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dc.contributor.authorPonnudurai, Ruby
dc.contributor.authorSayavedra, Lizbeth
dc.contributor.authorKleiner, Manuel
dc.contributor.authorHeiden, Stefan E
dc.contributor.authorThürmer, Andrea
dc.contributor.authorFelbeck, Horst
dc.contributor.authorSchlüter, Rabea
dc.contributor.authorSievert, Stefan M
dc.contributor.authorDaniel, Rolf
dc.contributor.authorSchweder, Thomas
dc.contributor.authorMarkert, Stephanie
dc.date.accessioned2018-11-07T17:09:40Z
dc.date.available2018-11-07T17:09:40Z
dc.date.issued2017-09-02
dc.date.updated2018-11-07T17:09:40Z
dc.description.abstractAbstract Bathymodiolus thermophilus, a mytilid mussel inhabiting the deep-sea hydrothermal vents of the East Pacific Rise, lives in symbiosis with chemosynthetic Gammaproteobacteria within its gills. The intracellular symbiont population synthesizes nutrients for the bivalve host using the reduced sulfur compounds emanating from the vents as energy source. As the symbiont is uncultured, comprehensive and detailed insights into its metabolism and its interactions with the host can only be obtained from culture-independent approaches such as genomics and proteomics. In this study, we report the first draft genome sequence of the sulfur-oxidizing symbiont of B. thermophilus, here tentatively named Candidatus Thioglobus thermophilus. The draft genome (3.1 Mb) harbors 3045 protein-coding genes. It revealed pathways for the use of sulfide and thiosulfate as energy sources and encodes the Calvin-Benson-Bassham cycle for CO2 fixation. Enzymes required for the synthesis of the tricarboxylic acid cycle intermediates oxaloacetate and succinate were absent, suggesting that these intermediates may be substituted by metabolites from external sources. We also detected a repertoire of genes associated with cell surface adhesion, bacteriotoxicity and phage immunity, which may perform symbiosis-specific roles in the B. thermophilus symbiosis.
dc.identifier.citationStandards in Genomic Sciences. 2017 Sep 02;12(1):50
dc.identifier.doihttps://doi.org/10.1186/s40793-017-0266-y
dc.identifier.urihttp://hdl.handle.net/1880/109107
dc.identifier.urihttps://doi.org/10.11575/PRISM/45041
dc.language.rfc3066en
dc.rights.holderThe Author(s).
dc.titleGenome sequence of the sulfur-oxidizing Bathymodiolus thermophilus gill endosymbiont
dc.typeunknown
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