Neural Respiratory Drive and Respiratory Muscle Function During CO2 Stimulation

Simple item page
dc.contributor.advisorEaston, Paul Alexander
dc.contributor.authorTagliabue, Giovanni
dc.contributor.committeememberZuege, Danny J.
dc.contributor.committeememberLeguillette, Renaud
dc.contributor.committeememberDay, Trevor
dc.date2022-11
dc.date.accessioned2022-06-24T19:43:27Z
dc.date.available2022-06-24T19:43:27Z
dc.date.issued2022-06-15
dc.description.abstractBackground. The use of EMG of the respiratory muscles as a surrogate of the central neural respiratory drive is gaining clinical popularity. Currently, the clinical EMG recording of the crural diaphragm by an esophageal electrodes probe (EAdi) is promoted as a “gold standard”. Additionally, other inspiratory muscles have been investigated as a less invasive alternative, especially the surface EMG of parasternal intercostal. Now there is major clinical interest focusing on the EMG of abdominal muscle as indicator of diaphragm weakness. However, all these clinical applications rely on physiological and technical assumptions that are not fully elucidated. Theme. The focus of this thesis is to address the following questions: 1) do crural and costal diaphragm share an identical neural-mechanical profile during inspiration? 2) does crural and costal diaphragm activity extend into, and contribute identically, during expiration? 3) does the parasternal intercostal share a similar neural activation with the diaphragm during inspiration? 4) is the current clinical technique, recording the surface EMG of parasternal intercostal? 5) is the expiratory phase a passive physiologic process, so that the activation of the abdominal muscles is a pathological indicator? Projects. This thesis is organized as a series of related projects, corresponding to individual chapters addressing each physiological question. The successful execution of this thesis work relied upon a model of a large, normal, intact mammals group, with intact airways, awake without anesthetic, at rest during spontaneous breathing. And, we did further measurements during progressive chemical stimulation by hypercapnia. Summary. We found that the crural and costal diaphragm each exhibit a distinct neural mechanical profile during inspiration, and the differentiation in their operational role extends into the early phase of expiration. Therefore, the clinical assumption that the crural diaphragm is representative of the whole diaphragm is not supported. Our results support the use of parasternal intercostal as a surrogate of neural respiratory drive. However, we confirmed that the current technique based on surface EMG is not reliable due to intrinsic physiologic limitations. Finally, our findings reinforce the concept that expiration is not a passive process but actively contributes to inspiration.en_US
dc.identifier.citationTagliabue, G. (2022). Neural Respiratory Drive and Respiratory Muscle Function During CO2 Stimulation (Doctoral thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca.en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/39854
dc.identifier.urihttp://hdl.handle.net/1880/114771
dc.language.isoengen_US
dc.publisher.facultyCumming School of Medicineen_US
dc.publisher.institutionUniversity of Calgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.en_US
dc.subjectRESPIRATORY MUSCLESen_US
dc.subjectHYPERCAPNIAen_US
dc.subjectEMGen_US
dc.subjectSONOMICROMETRYen_US
dc.subjectNEURAL RESPIRATORY DRIVEen_US
dc.subjectDIAPHRAGMen_US
dc.subjectPARASTERNAL INTERCOSTALen_US
dc.subjectTRANSVERSUS ABDOMINISen_US
dc.subjectCOSTAL DIAPHRAGMen_US
dc.subjectCRURAL DIAPHRAGMen_US
dc.subject.classificationAnimal Physiologyen_US
dc.subject.classificationBiophysics--Medicalen_US
dc.subject.classificationMedicine and Surgeryen_US
dc.titleNeural Respiratory Drive and Respiratory Muscle Function During CO2 Stimulationen_US
dc.typedoctoral thesisen_US
thesis.degree.disciplineMedicine – Medical Sciencesen_US
thesis.degree.grantorUniversity of Calgaryen_US
thesis.degree.nameDoctor of Philosophy (PhD)en_US
ucalgary.item.requestcopytrueen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ucalgary_2022_tagliabue_giovanni.pdf
Size:
7.48 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.62 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Open Theses and Dissertations