β-cyclodextrins modified with different chain lengths and their physical characterization with and without the attachment to gold nanoparticles.

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atmire.migration.oldid6142
dc.contributor.advisorHeyne, Belinda
dc.contributor.advisorLing, Chang-Chun
dc.contributor.authorLam, Wing Man
dc.contributor.committeememberCramb, David
dc.contributor.committeememberDerksen, Darren
dc.contributor.committeememberAnikovskiy, Max
dc.date.accessioned2017-10-18T22:20:25Z
dc.date.available2017-10-18T22:20:25Z
dc.date.issued2017
dc.date.submitted2017en
dc.description.abstractBeta-cyclodextrins (β-CDs) are a family of water soluble, naturally occurring cyclic oligosaccharides with a hydrophobic cavity that is used to host hydrophobic guest molecules. The numerous hydroxyl groups allow the native β-CD to be easily functionalized via synthetic modifications. By attaching modified CDs to the surface of gold nanoparticles (AuNPs) through a thiol moiety, its surface plasmon resonance effect can be taken advantage of. The AuNPs exhibit a photothermal effect upon irradiation which can alter the binding constant of guest molecules in β-CD hosts. Therefore, we attached novel β-CDs with different length ethylene glycol chains in hopes of studying in a distance-dependent manner the changes in the binding between the host and guest molecules. Prior to the attachment of the modified β-CDs to the surface of the AuNPs, Nile Red (NR) was utilized as a fluorescent guest to physically characterize the modified β-CDs.en_US
dc.identifier.citationLam, W. M. (2017). β-cyclodextrins modified with different chain lengths and their physical characterization with and without the attachment to gold nanoparticles. (Master's thesis, University of Calgary, Calgary, Canada). Retrieved from https://prism.ucalgary.ca. doi:10.11575/PRISM/28734en_US
dc.identifier.doihttp://dx.doi.org/10.11575/PRISM/28734
dc.identifier.urihttp://hdl.handle.net/11023/4224
dc.language.isoeng
dc.publisher.facultyGraduate Studies
dc.publisher.institutionUniversity of Calgaryen
dc.publisher.placeCalgaryen
dc.rightsUniversity of Calgary graduate students retain copyright ownership and moral rights for their thesis. You may use this material in any way that is permitted by the Copyright Act or through licensing that has been assigned to the document. For uses that are not allowable under copyright legislation or licensing, you are required to seek permission.
dc.subjectChemistry
dc.subjectChemistry--Organic
dc.subjectChemistry--Physical
dc.subject.otherCyclodextrin
dc.subject.otherNile Red
dc.subject.otherFluorescence
dc.subject.otherGold
dc.subject.otherNanoparticle
dc.titleβ-cyclodextrins modified with different chain lengths and their physical characterization with and without the attachment to gold nanoparticles.
dc.typemaster thesis
thesis.degree.disciplineChemistry
thesis.degree.grantorUniversity of Calgary
thesis.degree.nameMaster of Science (MSc)
ucalgary.item.requestcopytrue
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