What We Have Learned about Autism Spectrum Disorder from Valproic Acid

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dc.contributor.authorChomiak, Taylor
dc.contributor.authorTurner, Nathanael
dc.contributor.authorHu, Bin
dc.date.accessioned2018-09-27T11:45:32Z
dc.date.available2018-09-27T11:45:32Z
dc.date.issued2013-12-08
dc.date.updated2018-09-27T11:45:32Z
dc.description.abstractTwo recent epidemiological investigations in children exposed to valproic acid (VPA) treatment in utero have reported a significant risk associated with neurodevelopmental disorders and autism spectrum disorder (ASD) in particular. Parallel to this work, there is a growing body of animal research literature using VPA as an animal model of ASD. In this focused review we first summarize the epidemiological evidence linking VPA to ASD and then comment on two important neurobiological findings linking VPA to ASD clinicopathology, namely, accelerated or early brain overgrowth and hyperexcitable networks. Improving our understanding of how the drug VPA can alter early development of neurological systems will ultimately improve our understanding of ASD.
dc.description.versionPeer Reviewed
dc.identifier.citationTaylor Chomiak, Nathanael Turner, and Bin Hu, “What We Have Learned about Autism Spectrum Disorder from Valproic Acid,” Pathology Research International, vol. 2013, Article ID 712758, 8 pages, 2013. doi:10.1155/2013/712758
dc.identifier.doihttps://doi.org/10.1155/2013/712758
dc.identifier.urihttp://hdl.handle.net/1880/108303
dc.identifier.urihttps://doi.org/10.11575/PRISM/45061
dc.language.rfc3066en
dc.rights.holderCopyright © 2013 Taylor Chomiak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleWhat We Have Learned about Autism Spectrum Disorder from Valproic Acid
dc.typeJournal Article
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